Expression Analysis of Oxidative Stress Markers 8-hydroxydeoxyguanosine and Protein Carbonyl in Breast Cancer and Their associations with Certain Immunological and Tumor Markers.

Objective: Breast cancer (BC) is a heterogeneous disease, recognized as a major public health problem worldwide, with several risk factors including oxidative stress, an imbalance between the production of reactive oxygen species (ROS) and antioxidant capacity. The aim of this study is to evaluate oxidative stress markers 8-Hydroxydeoxyguanosine (8-OHdG) and protein carbonyl and their associations with pathological and immunohistochemical parameters as well as the immune system in particular Interleukin-6 (IL-6) in BC patients from western Algeria.

Methods: We analyzed serum concentrations of 8-OHdG and IL-6 by Eliza technique and protein carbonyl by derivatization of protein carbonyl groups with 2,4-dinitrophenylhydrazine (DNPH), then associated them with immunohistochemical and pathological parameters, as well as in the different molecular and histological groups of BC.

[Excess mortality during the COVID-19 pandemic in Algeria: The case of Oran Province].

Objective: This study aimed to estimate excess mortality during the COVID-19 pandemic in Oran between March 2020 and December 2022.

Method: Monthly all-cause data used to estimate excess mortality were modeled against the pre-pandemic period (January 2011-February 2020). Excess mortality between March 2020 and December 2022 was estimated using a quasi-Poisson regression.

Expression profile of interleukin-6, 4-hydroxy-2-nonenal, and hypoxia-inducible factor 1-α in women with breast cancer and their association with clinicopathological parameters.

Introduction: Breast cancer (BC) is the most common malignancy in women worldwide, representing a major public health burden. Therefore, there is a need to identify circulating biomarkers for the early detection of BC and to facilitate the diagnosis. Interleukin-6 (IL-6), 4-hydroxy-2-nonenal (4-HNE), and hypoxia-inducible factor 1-α (HIF-1α) are biomarkers involved in the initiation and progression of this disease.

[Cancer epidemiology in Algeria, 1996-2019].

Introduction: Cancer is a major public health problem in Algeria. The aim of this article was to estimate trends in cancer incidence in Oran, Algeria, over the period 1996-2019.

Patients And Methods: Nine cancer sites were analyzed.

[Overweight and obesity in children aged 6-11 years: prevalence and associated factors in Oran].

Introduction: Childhood obesity is a major public health problem throughout the world. The purpose of this study was to determine the prevalence and risk factors of overweight and obesity in school-attending children aged 6-11 years in Oran during the 2010-2011 school year.

Materials And Methods: 2,252 children (1,104 girls and 1,148 boys) aged 6-11 years from nine primary schools in Oran participated in the survey.