Hypersensitivities to non-steroidal anti-inflammatory drugs.

NSAIDs are the most commonly used medications worldwide and are responsible for almost 25% of adverse drug reactions. Such reactions can have different manifestations and can be immunologic or non-immunologic. The diagnosis is primarily based on the medical history, which can be difficult in patients receiving multiple medications.

Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.

Ovarian malignant germ cell tumors (OMGCTs) are heterogeneous tumors that are derived from the primitive germ cells of the embryonic gonad. OMGCTs are rare, accounting for about 2.6% of all ovarian malignancies, and typically manifest in adolescence, usually with abdominal pain, a palpable mass, and elevated serum tumor marker levels, which may serve as an adjunct in the initial diagnosis, monitoring during therapy, and posttreatment surveillance.

Hepatocellular carcinoma screening in patients with compensated hepatitis C virus (HCV)-related cirrhosis aware of their HCV status improves survival: a modeling approach.

Unlabelled: Because of the ongoing debate on the benefit of ultrasound (US) screening for hepatocellular carcinoma (HCC), we assessed the impact of screening on hepatitis C virus (HCV)-related compensated cirrhosis patients aware of their HCV status. A Markov model simulated progression from HCC diagnosis to death in 700 patients with HCV-related compensated cirrhosis aware of their HCV status to estimate life expectancy (LE) and cumulative death at 5 years. Five scenarios were compared: S1, no screening; S2, screening by currently existing practices (57% access and effectiveness leading to the diagnosis of 42% at Barcelona Clinic Liver Cancer stage [BCLC-0/A]); S3, S2 with increased access (97%); S4, S2 with an efficacy of screening close to that achieved in a randomized controlled trial leading to the diagnosis of 87% of patients at stage BCLC-0/A; S5, S3+S4.

PROPOSED MEASURES OF CONTROL MANAGEMENT OF THE GRAPE MOTH, LOBESIA BOTRANA DEN AND SCHIFF (LEPIDOPTERA: TORTRICIDAE), IN REFERENCE TO INFESTATION PERCENTAGES, YIELD LOSS AND ECONOMICS OF CONTROL IN EGYPT.

This study aims to evaluate the efficacy of five measures; including the release of two strains of Trichogramma, Bacillus thuringiensis (B.t.).

BIOEFFICACY OF PIPER RIBESIOIDES (PIPERACEAE) EXTRACTS AGAINST NILAPARVATA LUGENS STAL. (HOMOPTERA: DELPHACIDAE).

The extracts of stem and seeds of Piper ribesioides (Piperaceae) were prepared in hexane, dichloromethane, ethyl acetate and ethanol and evaluated for their efficacy against 3-day-old adult brown plant hoppers, Nilaparvata lugens Stal under laboratory conditions. The treatment was given topically and results suggest the dose dependent response related to exposure time. The ethyl acetate extract was the best with an LC50 = 738 ppm-, 24 h post-treatment.

EFFICIENCY OF PREPARED BAITS OF LONE OR/AND ADMIXED FOUR BOTANICAL OILS ON THE VIABILITY OF SUCCESSIVE RAISED GENERATIONS OF AGROTIS IPSILON (HUFNAGEL) (INSECTA: LEPIDOPTERA: NOCTUIDAE) AFTER TREATING THE PARENT ONES.

The present study is initiated to determine the toxic and delayed effects of four botanical oils on the greasy cutworm A. ipsilon, aiming to attain an alternative environmentally safe and effective phytochemicals against the insect-pest. Four botanical oils (camphor, red basil, menthol and rose oil) were added at rates of 0.

TOXIC ACTIVITY AND DELAYED EFFECTS OF FIVE BOTANICAL OILS ON THE FOLLOWING GENERATIONS OF AGROTIS IPSILON (HUFNAGEL) (INSECTA: LEPIDOPTERA: NOCTUIDAE) AFTER PARENTS TREATMENT.

The present study is carried out to evaluate the toxic efficiency and delayed effects of five botanical oils on the greasy cut worm Agrotis ipsilon (Lepidoptera: Noctuidae), as a trial for the attainment of a possible use of an alternative safe and effective phytochemicals against the insect-pest. So as to minimize or prevent the repeated usage of conventional insecticides, then reduce the environmental pollution as well as the occurring hazards to man and domestic animal due to the use of the pesticides alone. Four tested concentrations (0.

Effect of membranes on oxygen transfer rate and consumption within a newly developed three-compartment bioartificial liver device: Advanced experimental and theoretical studies.

A mathematical model is developed to predict oxygen transfer in the fiber-in-fiber (FIF) bioartificial liver device. The model parameters are taken from the constructed and tested FIF modules. We extended the Krogh cylinder model by including one more zone for oxygen transfer.

Impact of emerging hepatitis C virus treatments on future needs for liver transplantation in France: a modelling approach.

Background: In light of the impact of emerging hepatitis C virus treatments on morbidity and mortality, we sought to determine whether candidates for liver transplantation for hepatocellular carcinoma and decompensated cirrhosis will decrease sufficiently to match liver grafts for hepatitis C virus-infected patients.

Aims: Using a Markov model, we quantified future liver graft needs for hepatitis C virus-induced diseases and estimated the impact of current and emerging treatments.

Methods: We simulated progression of yearly-hepatitis-C-virus-infected cohorts from the beginning of the epidemic and calculated 2013-2022 candidates for liver transplantation up until 2022 without and with therapies.

Experimental evaluation and theoretical modeling of oxygen transfer rate for the newly developed hollow fiber bioreactor with three compartments.

Bioartificial liver support provides a bridge to transplantation which is at present the only proven specific treatment for acute liver failure. In this paper, a novel multi-coaxial hollow fiber bioreactor so-called "Fibre-in-Fibre FIF Bioartificial liver device" with three compartments is experimentally and mathematically studied. The mathematical model in this paper is an extension of Krogh cylinder model for hollow fibre devices by including one more zone for oxygen transfer, i.

Adipogenetic effects of retrofractamide A derivatives in 3T3-L1 cells.

In a previous study, retrofractamide A from the fruit of Piper chaba was shown to promote adipogenesis in 3T3-L1 cells. In the present study, retrofractamide A and its derivatives were synthesized, and their adipogenetic effects in 3T3-L1 cells were examined. Among the tested compounds, an amide composed of 9-(3',4'-methylenedioxyphenyl)-nona-2E,4E,8E-trienoic acid and an n-butyl or n-pentyl amine showed strongest activity.

Sacrococcygeal tumors: clinical characteristics and outcome of pediatric patients treated at South Egypt Cancer Institute. A retrospective analysis.

Background: Sacrococcygeal tumors (SCT) are relatively uncommon tumors affecting neonates, infants and children. The aim of this article is to clarify any special characterizations in natural history, clinical presentation and outcome of such tumors treated at South Egypt Cancer Institute, the only research center located in South Egypt.

Methods: A retrospective analysis of children with SCT treated at the Pediatric Oncology department South Egypt Cancer Institute, Assiut University between 2004 and 2010.

LSN MS guidelines for the management of multiple sclerosis.

Objective: The prevalence of multiple sclerosis (MS) in Lebanon is unknown, as there are no available or reliable epidemiological studies to date. The circumstances of Middle East countries are different from those of Europe and North America in terms of differential diagnoses and disease management. The aim of the conference is to establish guidelines for diagnosis, treatment, follow-up and management of patients with MS in Lebanon.

Assessment of genetic relatedness in the honeybee Apis mellifera L. (Hymenoptera: apidae) colonies by using microsatellite loci.

In this study the relatedness was estimated between mother queen's colony and her daughters' queens' colonies, by extracting DNA from their individual workers offspring (N= 20) and using five microsatellite loci. Locus As indicated more diversity in the length of alleles from 130 to 162 PB with frequency from 0.05 to 0.

Some ecological aspects on olive parlatoria scale, Parlatoria oleae (Colvee) infested plum and olive trees under irrigation system at Burg El-Arab area, Alexandria, Egypt.

Field studies were conducted under irrigation system at Burg El-Arab area (50 K.m. west of Alexandria city) to study some ecological aspects of Parlatoria oleae (Colvee) and its parasitoid, Aphytis maculicornis (Masi) that infested olive and plum trees during the two successive years of 2010 and 2011.

Anion-induced enantioselective cyclization of diynamides to pyrrolidines catalyzed by cationic gold complexes.

Only chiral anions do the job! Optically active gold complexes derived from substituted binol hydrogen phosphate catalyze the desymmetrizing cyclization of 1,4-diynamides. This reaction provides access to synthetically useful, chiral methylene pyrrolidines with an all-carbon-substituted quaternary stereocenter.

Comparative study between atorvastatin and losartan on high fat diet-induced type 2 diabetes mellitus in rats.

Obesity is often associated with chronic inflammatory state which contributes to the development of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). This study investigated the effects of single and combined administration of atorvastatin (ATOR, lipid-lowering drug) and losartan (LOS, angiotensin receptor antagonist) on metabolic disorders and inflammatory status that are implicated in the development of T2DM with the use of pioglitazone (PIO) as a standard antidiabetic drug. T2DM was induced in male rats by high-fat diet (HFD) feeding for 16 weeks.

Life span extension of Caenorhabditis elegans by novel pyridoperimidine derivative.

Zwitterions formed from the addition of triphenylphosphine to dialky acetylene-dicarboxylates attack the nucleus of both 1H-perimidine (1) and 1H-benzo[d]imidazole (9) to form novel pyrido[1,2,3-cd]perimidine and imidazo[4,5,1-ij]quinoline derivatives in moderate yields (64-72%). The biological activity of the products has been studied. Compound 3a was found to extend life span of wild type Caenorhabditis elegans under standard laboratory conditions.

Efficiency of guva and lemon grass fine dusts on the potato tuber moth Phthorimaea operculella (Zeller) (Lepidoptera: Gelechiidae).

The present study was initiated to elucidate the effect of potato tubers treatment using fine dusts of Psidium guajava, Cymbopogon citratus, talc powder and their progressive dilutions(w/w) on the fitness components of raised generations of the potato tuber moth (PTM), Phthorimaea operculella. Results showed a direct as well as cumulative delayed effect of the tested plants fine dusts, either alone or admixed with talc powder in progressive dilutions from 5% up to 50% w/w on the viability of developing immatures and potentiality of adult moths. The revealed effects of each of the tested crude plant fine dusts or talc powder alone and/or their progressive dilutions (w/w) could be explained briefly as gradual significant shortening of life span of both sexes, prolongation of larval duration, reduction in number of raised pupae, increase of malformed ones, sharp decrease in the rate of emerged moths, deposited eggs, and developing of immatures; According to lower used dilutions of each tested plant fine dust from 5% to 20%, the complete inhibition of reproductive potential of both adult sexes, the going on metamorphic development of deposited eggs and/or raised immatures of the following generation, after the treatment of parent one, had been revealed the following distinct failure of: a) F1 development after former treatment of parent generation with the higher concentrations of 30-50% of both tested plant fine dusts and the lower prepared dilutions (10% and 20% (w/w)) of both the tested Psidium guajava and (20% (w/w)) Cymbopogom citratus plant fine dusts, resulted in fewer number of the emerged moths that were unviable, weak, sterile and died before induction the F1 progeny, b) F2 development due to the former treatment of the parents with talc powder, Psidium guajava fine dusts alone or its prepared dilutions of (5% (w/w)) and Cymbopogom citratus dilution of (10%(w/w)) gave unviable weak and sterile moths unable to induce the F2 progeny, c) F3 development post former treatment of the parent generations with Cymbopogom citratus dilution of 5% (w/w) induced unviable sterile moths and died after emergence and d) F4 development owing to the former parent treatment with Cymbopogon citratus fine dust alone; The complete failure of each of the above mentioned generations could be attributed to the cumulative effect of induced recessive lethal genes in both sexes along the extended period of each of these following generations, post former treatment of parent one, causing apparent undesirable effects, that appeared at the beginning of each of them.

Different patterns of acid and alkaline phosphatases activities during embryogenesis and in emerged adults of Helicoverpa armigera (Lepidoptera: Noctuidae).

The acid phosphatase and alkaline phosphatase activities were studied in the developing eggs and in aging ovary and testis of pot-emerged adult of the cotton bollworm, Helicoverpa armigera at different time intervals from 0-72 hours. Acid phosphatase activity was higher than alkaline phosphatase and acts as cyclic during embryonic development. Alkaline phosphatase activity was slightly increased in the freshly laid eggs but decreased more sharply than acid phosphatase during embryonic development.

Comparative studies of semi-artificial diets on the biology and the bionomics of the European corn borer, Ostrinia nubilalis Hübner (Or.: Lepidoptera, Fam. : Pyralidae).

Comparative studies of two semi-artificial diets (S.A.1 and S.

Safety and efficacy of sorafenib in hepatocellular carcinoma: the impact of the Child-Pugh score.

Background: Sorafenib increases median survival and time to radiological progression in patients with advanced hepatocellular carcinoma, but its benefit for Child-Pugh B patients remains uncertain.

Aim: To evaluate the safety and efficacy of sorafenib in real-life clinical practice conditions and to assess the influence of Child-Pugh class B on safety and efficacy.

Methods: All patients treated with sorafenib for advanced hepatocellular carcinoma in our institution were included prospectively.

Impact of insulin resistance on sustained response in HCV patients treated with pegylated interferon and ribavirin: a meta-analysis.

Background & Aims: Recent studies suggested that SVR rates might be lower in HCV patients with insulin resistance (IR) than in patients without IR, but the extent of the impact of IR on treatment response has not been established. We aimed to confirm the role of IR assessed by the homoeostasis model assessment (HOMA-IR) on SVR and to determine its magnitude.

Methods: We performed meta-analysis of studies evaluating the impact of IR in HCV patients treated with pegylated interferon and ribavirin.