Publications by authors named "Mounira Tlili"
Hepatic and renal extracellular matrix (ECM) turnover associated with diabetes and potential beneficial effects of yellow lupin extract (YLE) need further investigations. The aim of this study was to explore the effect of yellow extract (YLE) on renal and hepatic ECM under diabetes. Composition of YLE performed by LC-ESI-MS.
View Article and Find Full Text PDFContext: Disorders associated with diabetes and the beneficial effects of pomegranate peel extract (PPE) were widely reported. However effect of diabetes and PPE on extracellular matrix (ECM) remodelling needs further investigation.
Objectives: The focus of this study was to investigate the involvement of diabetes in cardiac ECM and the beneficial effects of PPE.
Hepatotoxicity of vanadyl sulfate in nondiabetic and streptozotocin-induced diabetic rats.
Can J Physiol Pharmacol
November 2018
This study examined the effects of vanadyl sulfate (VOSO) on the livers of nondiabetic and streptozotocin-induced diabetic rats. Rats were divided into 6 groups. Groups 1, 2, and 3 consisted of nondiabetic rats that were, respectively, control animals or those receiving an intraperitoneal (i.
View Article and Find Full Text PDFRhus species are known in traditional medicine for their therapeutic virtue and their extracts showed numerous important properties including antimalarial, antimicrobial, antiviral, and hypoglycemic and anticonvulsant activities. Rhus tripartitum (Ucria) is a medicinal plant widely used in Tunisia folk medicine against chronic diarrhea and gastric ulcer. This study was designed to examine and antioxidant, anti-inflammatory and anticancer activities of four extracts of Rhus tripartitum root cortex with increasing solvent polarity (hexane, dichloromethane, methanol and water).
View Article and Find Full Text PDFThe present investigation aimed to study the antioxidant activity and hepatoprotective effects of ethyl acetate extract of R. oxyacantha root cortex (RE) against DDT-induced liver injury in male rats. The RE exhibited high total phenolic, flavonoid and condensed tannins contents.
View Article and Find Full Text PDFArticle Synopsis
- Rhus tripartita, a plant traditionally used in Tunisia to treat ulcers and diarrhea, was studied to confirm its antidiarrheal properties through its root methanolic extract (RRE).
- The antidiarrheal effects were tested in rats using various methods, revealing that RRE significantly reduced diarrhea symptoms in a dose-dependent manner, especially at 300mg/kg, similar to the standard drug loperamide.
- Additionally, RRE showed strong antibacterial activity against pathogenic bacteria and had no acute toxicity at doses up to 3g/kg, with preliminary tests indicating it contains beneficial compounds like flavonoids and tannins.
Article Synopsis
- Atmospheric vanadium levels are rising due to fossil fuel combustion, leading to increased exposure resulting in conditions like occupational bronchial asthma and bronchitis.
- Research found that the neuropeptide PACAP can effectively reverse airway hyperresponsiveness caused by vanadate exposure in rats, improving bronchial resistance and restoring lung tissue.
- PACAP works by not only dilating the airways but also reducing the inflammatory responses and oxidative stress associated with vanadate, suggesting that PACAP analogs could be a potential treatment for respiratory inflammatory disorders.