Reactive hemophagocytic lymphohistiocytosis: Epidemiological, clinico-biological and etiological profile.

Unlabelled: Hemophagocytic lymphohistiocytosis (HLH) is an hyperinflammatory state resulting from increased secretion of proinflammatory cytokines, which are responsible for clinical, biological and cytological manifestations.

Objective: The aim of our study is to describe the epidemiological, clinical, biological, etiological and evolutionary profile of HLH in Tunisia.

Methods: A retrospective study that involved patients, with images of hemophagocytosis in myelograms analyzed at the laboratory of biological hematology of the University Hospital "Hédi-Chaker" of Sfax-Tunisia, followed at these departments: hematology, internal medicine, department of infectious-diseases and department of gastroenterology, (June2017- May2021).

Ischemic Stroke in Young Tunisian Adults.

Introduction: Ischemic Stroke in young adults is a real public health problem; it's a major cause of disability, alters quality of life and has a great socio-economic impact.

Aim: determine risk factors and specify the etiology of arterial ischemic stroke in young Tunisian adults.

Methods: In this 5 years retrospective study (2015-2020), we included all young adults (18-50 years) admitted for arterial ischemic stroke (AIS).

Large spontaneous HBV DNA fluctuations and potential usefulness of a single-point measurement of combined HBV DNA and quantitative HBsAg for the exclusion of HBeAg-negative chronic hepatitis B: A prospective Tunisian cohort study.

Background And Study Aim: During the natural course of HBeAg-negative chronic hepatitis B (CHB), fluctuations in hepatitis B virus (HBV) DNA and alanine aminotransferase (ALT) levels are often observed, making the classification of patients difficult. We aimed to describe spontaneous short-term HBV DNA level fluctuations and to assess the usefulness of qHBsAg in Tunisian patients with HBeAg-negative chronic HBV infection.

Patients And Methods: We included 174 treatment-naive Tunisian patients with HBeAg-negative chronic HBeAg-negative HBV infection.

Tuberculosis in elderly: Epidemiological profile, prognosis factors and chronological trends in Southern Tunisia, 1995-2016.

Background: Tuberculosis (TB) has become a public health problem among elderly in developing countries with the gradual increase in life expectancy.

Aim/objective: This study aimed to analyze the prognosis factors and chronological trends of TB in elderly in Southern Tunisia.

Methods: A retrospective study was conducted.

Cystic lesions of the brain: Think of the hydatid cyst.

Background: Hydatidosis is an endemic parasitosis in Tunisia that affect mostly the liver and the lung. Brain involvment is rare.

Aim: To focus on diagnostic, therapeutic and evolutive characteristics of cerebral hydatidosis.

Clinical, laboratory and evolutionary features of abdominal tuberculosis in comparison with other forms of extrapulmonary tuberculosis.

Background/objectives: Tuberculosis is a multisystem disease that might affect any organ. Abdominal tuberculosis (ABT) represents 5-17% from all extrapulmonary tuberculosis (EPT) sites. We aimed to study the clinical, laboratory and evolutionary features of ABT cases and to identify predictive factors associated with ABT.

Epidemiological profile and performance of triage decision-making process of COVID-19 suspected cases in southern Tunisia.

Introduction: During an epidemic, screening processes can play a crucial role in limiting the spread of the infection. The aim of this study was to describe the epidemiological profile of COVID-19 suspected cases and to evaluate the performance of the triage process in predicting COVID-19 in Southern Tunisia.

Methods: It was a prospective study including all patients consulting to the Hedi Chaker University Hospital departments from March to June 2020.

[Acute osteomyelitis caused by community-acquired methicillin-resistant in children: about 15 cases].

The treatment of acute osteomyelitis is becoming more challenging since the emergence of community-acquired methicillin-resistant Staphylococcus aureus. We collected data on all patients with acute osteomyelitis caused by this germ over a period of 21 years (January 1995-December 2016) and we analyzed the peculiarities of this disorder. Our case series includes 15 children, with an average age of 9 years.

Prosthetic Valve Endocarditis: A Systematic Review.

Objective: prosthetic valve endocarditis is a rare but a life-threatening complication of brucellosis. It remains a diagnostic challenge. Optimal treatment of prosthetic valve endocarditis is debated.

Prevalence, chronological trends and predictors of treatment outcomes among patients with tuberculosis in Southern Tunisia across two decades (1995-2016).

Introduction: Tuberculosis (TB) is a communicable disease common worldwide. Influencing factors in TB outcomes include socio-demographics, as well as disease-related and treatment-related factors. This study aimed to analyze the prevalence trends of unsuccessful treatment outcomes in Southern Tunisia during 1995-2016 and to identify their risk factors.

Survival of an immuno-competent patient from splenic and gastric mucormycosis-case report and review of the literature.

Mucormycosis is a life-threatening disease responsible for a high mortality rate. The disease usually affects immuno-compromised patients. While all sites might be involved, gastrointestinal disease is rare, occurring for 5% to 13% of all mucormycosis cases.

Comparative analysis between tuberculous meningitis and other forms of extrapulmonary tuberculosis.

Introduction: Tuberculosis is a multisystem disease that may affect any organ or tissue. Tuberculous meningitis (TBM) is the most severe form of tuberculosis and commonly affects the brain. We aimed to study the epidemiological, clinical, therapeutic and evolutionary features of TBM among adults and to compare them with other forms of extrapulmonary tuberculosis.

Breast tuberculosis: a diagnosis not to be forgotten.

Objective: To study the clinical characteristics and imaging features of breast tuberculosis (TB) and to describe treatment.

Material And Methods: A retrospective study including all patients hospitalized in the infectious diseases department for breast TB between 1997 and 2018.

Results: Twenty-two women, with a mean age of 39±12 years, were identified.

The association between vitamin D deficiency and extrapulmonary tuberculosis: Case-control study.

Tuberculosis remains a public health issue worldwide. Identifying its risk factors, such as vitamin D deficiency, is mandatory so as to target the preventive strategies. We aimed to study the association between vitamin D deficiency and extrapulmonary tuberculosis.

Tuberculous and Brucellar Spondylodiscitis: Comparative Analysis of Clinical, Laboratory, and Radiological Features.

Study Design: This was a retrospective study.

Purpose: The aim was to compare the clinical, laboratory, radiological, and evolutionary features of tuberculous spondylodiscitis (TS) and brucellar spondylodiscitis (BS).

Overview Of Literature: Clinical presentation of spondylodiscitis varies according to the underlying etiology, among which brucellosis and tuberculosis represent the primary cause, in endemic countries.

Update on urogenital tuberculosis in Southern Tunisia: a review of a 26-year period.

Introduction: Tuberculosis affects commonly the lungs, but any other organs can be affected as well. Urogenital tuberculosis is usually misdiagnosed. In this perspective, we aimed to give an update on the epidemiological, clinical and evolutionary features of urogenital tuberculosis in Southern Tunisia.

Is there gender inequality in the epidemiological profile of tuberculosis?

Background: Worldwide, many more males than females were diagnosed with tuberculosis (TB) and died from it globally. In light of this, examining the gender differences among patients with TB is crucial to institute effective prevention, coverage and treatment.

Aim: To analyze gender differences in the epidemiological, clinical and evolutionary specificities of TB in Southern Tunisia.

Prognosis of urinary tract infections: predictive factors and role of Ramadan fasting.

Background: The role of Ramadan fasting (RF) as a predictive factor of urinary tract infection (UTI) recurrence was controversially discussed in the literature.

Aim: The present study aimed to identify the prognosis factors of recurrent UTIs.

Methods: Data were retrospectively collected from patients with UTI diagnosed at the infectious diseases department and its affiliated outpatient department in Hedi Chaker University Hospital, Sfax, Tunisia, between 2010 and 2017.

Combination of amphotericin B and caspofungin in the treatment of mucormycosis.

We report a case of invasive mucormycosis in 52 year-old woman. CT-scan and magnetic resonance imaging found a partial right sinus thrombosis associated with homolateral ethmoidal and maxillary sinusitis with submucosal inflammation. Histopathological examination of excised tissue was positive for mucormycosis.

Presumed Tuberculous uveitis: clinical features and management.

Aim: To illustrate the various clinical features and management of presumed tuberculous uveitis in an endemic area in Tunisia.

Methods: This is a retrospective study including 14 patients (26 eyes) diagnosed with presumed tuberculous uveitis at the Department of Ophthalmology Habib Bourguiba University Hospital of Sfax-Tunisia.

Results: Mean age at onset was 31.

Epidemiology and disease burden of tuberculosis in south of Tunisia over a 22-year period: Current trends and future projections.

Background: Tuberculosis (TB) is a public health problem worldwide. Characterizing its trends over time is a useful tool for decision-makers to assess the efficiency of TB control programs. We aimed to give an update on the current chronological trends of TB in Southern Tunisia from 1995 to 2016 and to estimate future trajectories of TB epidemic by 2030.

Evaluation of the influenza-like illness surveillance system in Tunisia, 2012-2015.

Background: This study was initiated to evaluate, for the first time, the performance and quality of the influenza-like illness (ILI) surveillance system in Tunisia.

Methods: The evaluation covered the period of 2012-2015 and used different data sources to measure indicators related to data quality and completeness, representativeness, timeliness, simplicity, acceptability, flexibility, stability and utility.

Results: During the evaluation period, 485.

Performance of an Easy and Simple New Scoring Model in Predicting Multidrug-Resistant Enterobacteriaceae in Community-Acquired Urinary Tract Infections.

Background: Multidrug resistance (MDR) is a growing global problem in bacterial community-acquired urinary tract infections (CUTIs). We aimed to propose an easy-to-use clinical prediction model to identify patients with MDR in CUTI.

Methods: We conducted a retrospective study including 770 patients with documented CUTI diagnosed during 2010-2017.