Publications by authors named "Mounier Jeremy"
Background: Flow diverting stents (FDS) have transformed the treatment of intracranial aneurysms; however, their metallic structure associated with their intra-luminal positioning hamper angiographic and clinical outcomes. Therefore, there is a need to develop FDS with optimized surfaces that reduce thrombogenicity while promoting the healing process and endothelialization.
Methods: P8RI, a peptide mimicking the CD31 protein, was previously developed and grafted onto Silk Vista (SV) FDS.
Article Synopsis
- The study compares the endothelial coverage of new coated and uncoated flow diverters (FDs) in rabbits, focusing on the effects of different antiplatelet therapies.
- Three types of FDs were implanted in rabbits, and their integration into the arterial wall was assessed after four weeks using various imaging and histopathological techniques.
- Results show that the integration of coated and uncoated FDs is similar, while the antiplatelet regimen influenced the rates of coverage, with no therapy showing the highest rate of neointimal formation.
Article Synopsis
- Recanalization of coiled aneurysms is a persistent issue, and the study tests fucoidan-coated coils to enhance healing after embolization compared to bare platinum and dextran-coated coils.
- The research involved a feasibility study on rabbits, where aneurysms were treated and assessed for healing through imaging and histological analysis one month post-embolization.
- Findings indicate the fucoidan group exhibited significantly improved collagen presence and healing at the aneurysm neck compared to the bare platinum group, suggesting it may be a promising approach for enhancing aneurysm healing in future applications.
WEB shape modifications: angiography-histopathology correlations in rabbits.
J Neurointerv Surg
February 2024
Background: WEB Shape Modification (WSM) over time is frequent after aneurysm treatment. In this study, we explored the relationship between histopathological changes and angiographic evolution over time in experimental aneurysms in rabbits treated with the Woven EndoBridge (WEB) procedure.
Methods: Quantitative WSM was assessed using flat-panel computed tomography (FPCT) during follow-up by calculating height and width ratio (HR, WR), defined as the ratio between either measurement at an index time point and the measurement immediately after WEB implantation.
Article Synopsis
- The study examines the process of coil healing in intracranial aneurysms (IAs) using an animal model, highlighting the issues with recanalization that can affect treatment outcomes.
- 27 aneurysms in rabbits were analyzed one month post-coiling through traditional histology and advanced imaging techniques to assess healing.
- A five-stage classification of aneurysm healing was developed using nonlinear microscopy, providing a more precise evaluation tool for the effectiveness of embolization devices.*
Endovascular treatment is the first-line therapy for most intracranial aneurysms; however, recanalisation remains a major limitation. Developments in bioengineering and material science have led to a novel generation of coil technologies for aneurysm embolisation that address clinical challenges of aneurysm recurrence. This review presents an overview of modified surface coil technologies and summarises the state of the art regarding their efficacy and limitations based on experimental and clinical results.
View Article and Find Full Text PDFMultiple myeloma (MM) is a plasma cell cancer and represents the second most frequent hematologic malignancy. Despite new treatments and protocols, including high-dose chemotherapy associated with autologous stem cell transplantation, the prognosis of MM patients is still poor. α-radioimmunotherapy (α-RIT) represents an attractive treatment strategy because of the high-linear-energy transfer and short pathlength of α-radiation in tissues, resulting in high tumor cell killing and low toxicity to surrounding tissues.
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