Publications by authors named "Mouneeb M Choudry"
Article Synopsis
- Large language model (LLM) chatbots, like ChatGPT and Bard, can provide information about benign prostatic hyperplasia surgery, with their response quality improving significantly when prompted with specific criteria.
- A study evaluated the information quality and readability of these chatbots, finding that unprompted answers were rated moderately, but prompting improved the quality substantially.
- Overall, while the chatbots were generally accurate and complete in responding to simulated patient queries, the readability of their responses was poor, indicating a need for improvement in patient education materials.*
Background: The psychological and cardiovascular health impacts on family members of patients who have been diagnosed with cancer have not been well characterized. The purpose of this study is to determine whether a family member's cancer diagnosis influences the risk of psychological illness and cardiovascular disease in first-degree relatives and spouses of patients affected by cancer.
Methods: This retrospective cohort analysis evaluated the risk of psychological illness and cardiovascular disease in first-degree relatives and spouses of patients diagnosed with a genitourinary cancer between 1990 and 2015 compared to relatives of those not diagnosed with a genitourinary cancer.
Postoperative stress urinary incontinence (SUI) after Holmium Laser Enucleation of the Prostate (HoLEP) has improved with the early apical release (EAR) technique. However, some patients develop SUI despite using EAR HoLEP. The aim of this study is to investigate whether a novel classification of the external sphincter is correlated with postoperative SUI.
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- AI integrates human tasks into machines, playing an evolving role in evaluating and managing kidney cancer.
- A narrative review was conducted using the PubMed database, focusing on various AI methods (like machine learning and neural networks) in kidney cancer research.
- The review identified 72 significant studies on imaging and pathology, highlighting the potential for AI tools to influence future clinical decisions for kidney cancer.
Purpose: This study aimed to investigate the prevalence of pathogenic germline variants (PGVs) in hereditary cancer genes utilizing a universal testing approach and to determine the rate of PGVs that would have been missed based on National Comprehensive Cancer Network (NCCN) guidelines in genitourinary (GU) malignancies.
Materials And Methods: A multisite, single-institution prospective germline genetic test (GGT) was universally offered to patients with new or active diagnoses of GU malignancies (prostate, bladder, and renal) from April 2018 to March 2020 at Mayo Clinic sites. Participants were offered GGT using a next-generation sequencing panel of > 80 genes.
Objective: To evaluate outcomes of robotic-assisted transplant ureteral repair (RATUR) for the management of kidney transplant ureteral strictures (TUS).
Methods: We retrospectively analyzed 41 consecutive patients who underwent RATUR for TUS at multiple tertiary referral centers between January 2016 and December 2022. RATUR was performed utilizing a robotic-assisted transperitoneal approach.
Objective: To investigate the difference in postoperative incontinence and quality of life comparing standard vs early apical release (EAR) Holmium Laser Enucleation of the Prostate (HoLEP).
Methods: A retrospective review was performed to identify patients who underwent HoLEP from December 2021 to December 2022 at a single tertiary referral center with two participating consultant urologists. Patients were assessed with questionnaires and evaluated clinically.
Introduction: Bacillus Calmette-Guerin (BCG) is the most effective therapy available to treat high-risk nonmuscle invasive bladder cancer (NMIBC) patients. However, for patients with immunomodulating conditions BCG is a relative contraindication due to efficacy and safety concerns. To our knowledge, no population-level study evaluating the efficacy and safety profile of BCG for immunomodulated patients exists.
View Article and Find Full Text PDFIntroduction: No professional society guidelines recommend PSA screening in men younger than age 40; however, data suggest testing occurs at meaningful rates in this age group. The purpose of this study was to identify the rate of PSA testing in men under 40.
Methods: This is a population-based, retrospective cohort study from 2008 to 2017.
Article Synopsis
- A study was conducted to evaluate the impact of the Choosing Wisely campaign on the use of imaging for men with newly diagnosed prostate cancer, focusing on reducing unnecessary procedures.
- Analysis of Medicare data from 2007 to 2015 showed a significant decrease in imaging utilization among low-risk patients, with declines in CT and nuclear medicine bone scans.
- Although the campaign has led to a decrease in unnecessary imaging for low-risk patients, imaging for high-risk patients remains high, suggesting ongoing challenges in promoting guideline-concordant care.
The intense inflammatory response triggered in the brain after focal cerebral ischemia is detrimental. Recently, we showed that the suppression of toll-like receptors (TLRs) 2 and 4 attenuates infarct size and reduces the expression of pro-inflammatory cytokines in the ischemic brain. In this study, we further examined the effect of unsuppressed induction of TLRs 2 and 4 on the expression of its downstream signaling molecules and pro-inflammatory cytokines 1 week after reperfusion.
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