Publications by authors named "Mouna Aounallah"
Unlabelled: Early HIV-1 infection is characterized by enhanced tryptophan catabolism, which contributes to immune suppression and disease progression. However, the mechanism by which kynurenine, a tryptophan-related metabolite, induces immune suppression remains poorly understood. Herein, we show that the increased production of kynurenine correlates with defective interleukin-2 (IL-2) signaling in memory CD4 T cells from HIV-infected subjects.
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- HIV-1 infection causes a loss of CD4 T-cells and is linked to ongoing immune inflammation and metabolic changes, which have not been prioritized in treatment strategies traditionally focused on T-cell recovery.
- Recent studies highlight the importance of understanding how inflammation (especially through the inflammasome) and metabolic alterations affect immune responses in chronic infections like HIV-1.
- Current antiretroviral therapies (ART) only partially alleviate inflammation and do not fully improve metabolism, indicating a need for new approaches to enhance immune function and overall quality of life for those with HIV-1.
Article Synopsis
- - HIV-1 infection causes long-lasting immune system activation and inflammation, which persists even with antiretroviral therapy, making it hard to fully restore immune health.
- - The virus uses specific proteins to manipulate the host's cellular processes, enhancing its replication and spread while disturbing the balance of immune responses.
- - Understanding how HIV-1 disrupts immune metabolism could lead to new treatments aimed at restoring immune function in infected individuals.