A characteristic function based circular distribution family and its goodness of fit : The flexible wrapped Linnik family.

In this article, the primary aim is to introduce a new flexible family of circular distributions, namely the wrapped Linnik family which possesses the flexibility to model the inflection points and tail behavior often better than the existing popular flexible symmetric unimodal circular models. The second objective of this article is to obtain a simple and efficient estimator of the index parameter of symmetric Linnik distribution exploiting the fact that it is preserved in the wrapped Linnik family. This is an interesting problem for highly volatile financial data as has been studied by several authors.

Mitigation of Breast Cancer Cells' Invasiveness via Down Regulation of ETV7, Hippo, and PI3K/mTOR Pathways by Vitamin D3 Gold-Nanoparticles.

Metastasis in breast cancer is the major cause of death in females (about 30%). Based on our earlier observation that Vitamin D3 downregulates mTOR, we hypothesized that Vitamin D3 conjugated to gold nanoparticles (VD3-GNPs) reduces breast cancer aggressiveness by downregulating the key cancer controller PI3K/AKT/mTOR. Western blots, migration/invasion assays, and other cell-based, biophysical, and bioinformatics studies are used to study breast cancer cell aggressiveness and nanoparticle characterization.

Corrigendum: USP14 as a therapeutic target against neurodegeneration: a rat brain perspective.

[This corrects the article DOI: 10.3389/fcell.2020.

Calcineurin inhibition protects against dopamine toxicity and attenuates behavioral decline in a Parkinson's disease model.

Background: Parkinson's disease (PD), a highly prevalent neuro-motor disorder is caused due to progressive loss of dopaminergic (DAergic) neurons at substantia nigra region of brain. This leads to depleted dopamine (DA) content at striatum, thus affecting the fine tuning of basal ganglia. In patients, this imbalance is manifested by akinesia, catalepsy and tremor.

Novel Data Transmission Schemes for Inter-WBAN Networks Using Markov Decision Process.

This work proposes a stochastic model of the coordinator units of each wireless body area network (WBAN) in a multi-WBAN scenario. In a Smart Home environment, multiple patients can come into the vicinity of each other while each of them is wearing a WBAN configuration for monitoring body vitals. Thus, while multiple WBANs coexist, the individual WBAN coordinators require adaptive transmission strategies in order to balance between maximizing the likelihood of data transmission and minimizing the chances of packet loss due to inter-BAN interference.

Total synthesis of haploscleridamine, villagorgin A and an approach towards lissoclin C.

An investigation of asymmetric total syntheses of three indole-imidazole alkaloids from histidine are described. A common advanced piperidinone was contructed a ring-closing metathesis which was then subjected to a modified Fischer indole synthesis. Deprotection of an -tosyl group a dissolving metal reduction affords haploscleridamine which upon reaction with aqueous formaldehyde in trifluoroethanol provided villagorgin A.

Class-Wise Subspace Alignment-Based Unsupervised Adaptive Land Cover Classification in Scene-Level Using Deep Siamese Network.

In this article, an unsupervised domain adaptation strategy has been investigated using a deep Siamese neural network in scene-level land cover classification using remotely sensed images. At the onset, the soft class label and probability scores of each target sample have been obtained using a pretrained model of a deep convolutional neural network. Thereafter, a semiautomatic threshold selection algorithm along with a graph-based approach has been explored to obtain the "most-confident" target samples.

Direct utilization of industrial carbon dioxide with low impurities for acetate production via microbial electrosynthesis.

The present study aimed to demonstrate the utilization of unpurified industrial CO with low impurities for acetate production via microbial electrosynthesis (MES) for the first time. In MES experiments with CO-rich brewery gas, the enriched mixed culture dominated by Acetobacterium produced 1.8 ± 0.

USP14 as a Therapeutic Target Against Neurodegeneration: A Rat Brain Perspective.

In the recent past, many of the deubiquitinases (DUB) were found to modulate mitochondrial clearance or mitophagy and thus they are currently projected as therapeutic targets against neurodegeneration. Among these DUBs, USP14 stands at a distinctive juncture, since it can influence both proteasome complex activity and autophagy process. USP14 interference can enhance mitochondrial clearance and thus can protect Parkinsonian phenotypes in model.

Investigating mitochondrial autophagy by routine transmission electron microscopy: Seeing is believing?

Mitochondrial autophagy is affected in many diseases. In the past few years, the multiple-steps process of selective degradation of mitochondria has been dissected in details by combining outcomes from different approaches. Perhaps one of the most rigorous methods to clearly visualise mitochondria undergoing autophagic engulfment and degradation, is transmission electron microscopy (TEM).

Designing Transmission Strategies for Enhancing Communications in Medical IoT Using Markov Decision Process.

The introduction of medical Internet of Things (IoT) for biomedical applications has brought about the era of proactive healthcare. Such advanced medical supervision lies on the foundation of a network of energy-constrained wearable or implantable sensors (or things). These miniaturized battery-powered biosensor nodes are placed in, on, or around the human body to measure vital signals to be reported to the sink.

Iron-Catalyzed Allylic Amination Directly from Allylic Alcohols.

Allylic amination, directly from alcohols, has been demonstrated without any Lewis acid activators using an efficient and regiospecific molecular iron catalyst. Various amines and alcohols were employed and the reaction proceeded through the oxidation/reduction (redox) pathway. A direct one-step synthesis of common drugs, such as cinnarizine and nafetifine, was exhibited from cinnamyl alcohol that produced water as side product.

Work-exposure to PM and aromatic volatile organic compounds, excretion of urinary biomarkers and effect on the pulmonary function and heme-metabolism: A study of petrol pump workers and traffic police personnel in Kolkata City, India.

This study focused work-exposure to particulate matter ≤ 10 µm (PM), volatile organic compounds (VOCs) and biological monitoring of major VOCs (BTEX) to observe the significant effects of traffic related pollutants on respiratory and hematological systems of workers engaged in two occupational settings, petrol pumps and traffic areas of Kolkata metropolitan city, India. PM was assessed by personal sampling and particle size distribution by 8-stage Cascade Impactor. VOCs were analysed by gas chromatography-flame ionization detector (GC-FID) and five urinary metabolites, trans trans- mercapturic acid (tt-MA), S-phenyl mercapturic acid (SPMA), hippuric acid (HA), mandelic acid (MA) and methyl hippuric acid (MHA) of VOCs, benzene, toluene, ethyl benzene and xylenes (BTEX) by reverse phase high performance liquid chromatography (HPLC).

Ameliorative effects of glycyrrhizin on streptozotocin-induced diabetes in rats.

Objectives: Glycyrrhizin is the main water-soluble constituent of the root of liquorice (Glycyrrhiza glabra). The study investigates the effect of glycyrrhizin on streptozotocin (STZ)-induced diabetic changes and associated oxidative stress, including haemoglobin-induced free iron-mediated oxidative reactions.

Methods: Male Wistar rats were grouped as normal control, STZ-induced diabetic control, normal treated with glycyrrhizin, diabetic treated with glycyrrhizin and diabetic treated with a standard anti-hyperglycaemic drug, glibenclamide.

Action of pelargonidin on hyperglycemia and oxidative damage in diabetic rats: implication for glycation-induced hemoglobin modification.

Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with emphasis on its role against pathological oxidative stress including hemoglobin-mediated free radical reactions.