Free radical induced activity of an anthracycline analogue and its Mn complex on biological targets through electrochemical generation of semiquinone.

Cytotoxicity by anthracycline antibiotics is attributed to several pathways. Important among them are formation of free-radical intermediates. However, their generation makes anthracyclines cardiotoxic which is a concern on their use as anticancer agents.

The importance of pK in an analysis of the interaction of compounds with DNA.

pK of a compound is crucial for determining the contributions of different forms of it towards overall binding with DNA. Hence it is important to use correct pK values in DNA interaction studies. This study takes a look at the importance of pK values to realize binding of compounds with DNA.