Insights into the role of histone lysine demethylases in bone homeostasis and skeletal diseases: A review.

Histone lysine demethylases (KDMs), as important epigenetic regulators, are involved in various biological processes such as energy metabolism, apoptosis, and autophagy. Recent research shows that KDMs activate or silence downstream target genes by removing lysine residues from histone tails, and participate in the regulation of bone marrow mesenchymal stem cells (BM-MSCs), osteoblasts (OB), osteoclasts (OC), chondrocytes and other skeletal cell development, differentiation and formation. Moreover, several members of the KDM family affect the occurrence and development of bone diseases such as osteoporosis (OP), osteoarthritis (OA), osteosarcoma (OS), by regulating target genes.

3D printed porous PEEK scaffolds with stable and durable gelatin composite hydrogel coating loaded Yoda1 for in vivo osseointegration.

Polyetheretherketone (PEEK) has emerged as a promising material for bone substitution; however, its limited osseointegration hinders its clinical applications. This research employs a porous structural design alongside surface modification techniques to improve the osseointegration properties of PEEK. Porous PEEK scaffolds were fabricated via 3D printing technology, followed by the application of a stable coating of Yoda1-loaded methacrylated gelatin (GelMA) on their surfaces.

Online PGC-LC-MS analysis of colonic mucin O-glycans in ovalbumin-induced food allergy in Balb/c mice by treatment with sea cucumber chondroitin sulfate polysaccharide.

The highly sulfated polysaccharide sea cucumber chondroitin sulfate (SCCS) can alleviate intestinal damage and display strong anti-food-allergic activity. The O-glycopattern levels in colonic mucin are closely related to the its protective effect on function of the intestinal barrier. However, the effect of the SCCS on colonic mucin O-glycan has not been investigated.

Predictors of failure to rescue after fenestrated-branched endovascular aortic repair of thoracoabdominal aortic aneurysms.

Objective: Failure to rescue (FTR), defined as mortality due to failure in responding to in-hospital complications, is an important quality indicator. This study aimed to assess incidence and predictors for FTR among centers performing fenestrated-branched endovascular aortic repair (FB-EVAR) of thoracoabdominal aortic aneurysms (TAAA).

Methods: Consecutive patients treated by FB-EVAR for TAAAs between 2005 and 2022 in 27 centers of the International Multicenter Aortic Research Group were analyzed.

The mitochondrial protease ClpP is a promising target for multiple myeloma treatment.

Drug resistance and relapse are the major obstacles in multiple myeloma (MM) treatment, driving the search for novel therapeutics. The chemoactivation of mitochondrial caseinolytic protease P (ClpP) has shown to have anticancer effects on many tumors, but has seldom been elucidated in MM. Here we found that the CLPP expression was elevated in MM patients, and further increased in relapsed cases.

Effects of Long-Term Cocaine Self-Administration on Kappa Opioid Receptors in Socially Housed Cynomolgus Monkeys as Assessed with PET Imaging and Neuronally Derived Exosomes.

Background: The present study utilized PET imaging to examine how long-term cocaine self-administration (SA) and time-off from cocaine affected kappa opioid receptor (KOR) availability in the brain of previously cocaine-naïve monkeys. In addition, neuronally derived small extracellular vesicles (NDEs) were measured from plasma to identify peripheral measures of KORs.

Methods: Female (n=6) and male (n=7) cynomolgus monkeys, living in stable same-sex social groups, were trained to SA intravenous cocaine.

Piperlongumine induces ROS accumulation to reverse resistance of 5-FU in human colorectal cancer via targeting TrxR.

Resistance is a major concern for colorectal cancer patients undergoing chemotherapy. Piperlongumine (PL) has been proven to effectively reverse drug resistance in several types of cancers; however, the mechanisms associated with the reversal effect and the targets of PL in cancer drug resistance are still unclear. In this research, the reversal effects and associated mechanisms of PL in 5-Fluorouracil (5-FU) resistance colorectal cancer were investigated both in vitro and in vivo.

Maresin 1 Attenuates Myocardium Ischemia/Reperfusion Injury via SIRT1/HMGB-1/NLRP-3-Related Mechanisms.

Background And Purpose: Maresin 1 (MaR 1) has demonstrated potent anti-inflammatory and antioxidant effects in different animal models. However, its impact on heart ischemia/reperfusion injury (IRI) remains uncertain. Pyroptosis, a pro-inflammatory programmed cell death, is associated with IRI.

Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions.

The neurofilaments formed by hyperphosphorylated tau is a hallmark of tauopathies. However, the biological functions of tau and the physiological significance of its phosphorylation are still not fully understood. By using human tau (441 a.

Network pharmacology-based exploration of the mechanism of Wenweishu granule in treating chronic atrophic gastritis with spleen-stomach cold deficiency syndrome.

Ethnopharmacological Relevance: Wenweishu (WWS) is a traditional Chinese medicine compound formulated for chronic atrophic gastritis (CAG) treatment by warming the stomach and alleviating pain. However, its pharmacological mechanisms remain underexplored.

Aim Of The Study: This study investigated the therapeutic effects and potential mechanisms of WWS on CAG with spleen-stomach cold deficiency syndrome (SSCDS).

Innovative injectable, self-healing, exosome cross-linked biomimetic hydrogel for cartilage regeneration.

The limited self-healing capacity of cartilage hinders its repair and regeneration at the defect sites. Recent research into small-molecular compounds has shown promise in achieving a better regeneration of cartilage. In this study, we encapsulate kartogenin (KGN) and transforming growth factor β1 (TGF-β1) within mesenchymal stem cells derived exosomes (EKT), and then coated them with succinylated chitosan (sCH) to create positively charged exosomes, termed CEKT.

Estimates and projections in the economic impacts of 15 dietary risk factors for 204 countries and territories from 2020 to 2050: a health-augmented macroeconomic modelling study.

Background: Suboptimal diet results in significant health and economic burdens. However, the global economic costs of dietary risks remain unclear.

Objective: This study aimed to estimate the macroeconomic burden of 15 dietary risk factors in 204 countries and territories from 2020-2050.

Non-Funduscopic Slit Lamp Assessment of the Posterior Hyaloid Membrane - A Simpler and More Effective Way of Clinically Diagnosing Posterior Vitreous Detachments.

Purpose: To assess the clinical utility of a simpler method of detecting a complete posterior vitreous detachment (PVD) - visualization of the posterior hyaloid membrane at the slit lamp - which does not require expert dilated fundus examination skills, special instrumentation (fundoscopy lenses), or imaging devices (OCT or B-scan).

Design: Cross-sectional case series PARTICIPANTS: All eligible patients presenting to the retina clinic during the study period were consecutively examined.

Methods: All patients were examined for the presence or absence of a PVD using the posterior hyaloid membrane assessment method, Weiss ring assessment method, and via optical coherence tomography (OCT) performed by three masked graders.

Fluoroscopic visualization in ankle surgery: Evaluating the effects of lateral malleolus fixation order.

Ankle fractures, particularly those involving the lateral and posterior malleolus, are complex injuries requiring careful surgical management. This study investigates how the sequence of lateral malleolus fixation affects the intraoperative visualization of the posterior malleolus fracture during fluoroscopy. A retrospective and prospective approach was used, comparing outcomes in patients who underwent surgery for combined lateral and posterior malleolar fractures.

A gut bacterial supplement for Asian honey bee (Apis cerana) enhances host tolerance to nitenpyram: Insight from microbiota-gut-brain axis.

The widespread use of neonicotinoid pesticides has severely impacted honey bees, driving population declines. Gut microbiota are increasingly recognized for their role in mitigating pesticide toxicity. This study evaluated the ability of Gilliamella sp.

Tunable nitrogen vacancies on g-CN for efficient photocatalytic CO reduction and H production.

Vacancy defects can enhance the surface activity of photocatalyst by providing additional reactive sites, facilitating the adsorption and transformation of reactants. Therefore, by tuning the type and concentration of vacancy defects, the performance of photocatalyst can be optimized, thereby increasing their application potential in environmental remediation and energy conversion. In this work, tunable nitrogen vacancies g-CN photocatalysts were prepared and treated by sodium hypophosphite (NHPO) with reducibility.

Comparison of cognitive behavioral therapy and third-wave-mindfulness-based therapies for patients suffering from depression measured using the Beck-Depression-Inventory (BDI): A systematic literature review and network-meta-analysis.

Background: Mindfulness-based therapies (MBT) are proposed as a "third wave" of cognitive-behavioral therapy (CBT). This network meta-analysis investigated this hypothesis by comparing the effectiveness of MBT and CBT for treating depression, measured by the Beck Depression Inventory-II (BDI-II).

Methods: An indirect comparison was made.

Correlations and network analysis between food intake and depression among Chinese rural elderly based on CLHLS 2018.

Background: Implementing effective interventions for specific depressive symptoms is of vital importance to reduce the disease burden of depression. Previous studies have identified links between various dietary patterns and depression among elderly individuals. However, associations between food consumption and specific depressive symptoms remained largely unknown.

Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review.

Cardiovascular disease is one of the main causes of mortality worldwide. Andrographolide represents an important category of natural phytochemicals that has significant therapeutic potential in various conditions such as acute lung injury, heart disease, and viral infections due to its anti-oxidative, anti-inflammatory, and anti-apoptotic properties. This compound plays a protective role in human pathophysiology.

Clinical efficacy of end-to-end anastomosis followed by mucosal folding and burying in minimally invasive esophageal cancer surgery.

Background: Esophageal cancer is a common malignancy in China, with anastomotic fistula being a major postoperative complication. This study compares the clinical outcomes of end-to-end anastomosis and end-to-end anastomosis with mucosal folding and burying in minimally invasive esophageal cancer surgery.

Methods: From October 2020 to March 2023, patients with esophageal cancer who underwent laparoscopic three-incision cervical anastomosis at the Fourth People's Hospital of Zigong City, were radomly assigned to receive either end-to-end anastomosis or end-to-end anastomosis followed by mucosal folding and burying.

Hypoxia inducible factor-1α drives cancer resistance to cuproptosis.

Cuproptosis represents a new type of cell death that intricately associated with copper homeostasis and protein lipoylation. The cuproptosis suppression has been characterized in the hypoxic tumor microenvironment (TME). Here we reveal that hypoxia inducible factor-1α (HIF-1α) is a driver of cuproptosis resistance in solid tumor.

The amphipod genome reveals population dynamics and adaptations to hadal environment.

The amphipod Hirondellea gigas is a dominant species inhabiting the deepest part of the ocean (∼6,800-11,000 m), but little is known about its genetic adaptation and population dynamics. Here, we present a chromosome-level genome of H. gigas, characterized by a large genome size of 13.

Microbial ecosystems and ecological driving forces in the deepest ocean sediments.

Systematic exploration of the hadal zone, Earth's deepest oceanic realm, has historically faced technical limitations. Here, we collected 1,648 sediment samples at 6-11 km in the Mariana Trench, Yap Trench, and Philippine Basin for the Mariana Trench Environment and Ecology Research (MEER) project. Metagenomic and 16S rRNA gene amplicon sequencing generated the 92-Tbp MEER dataset, comprising 7,564 species (89.

Profiles of moral sensitivity and their associated factors in nursing students: A latent profile analysis.

Aim: This study was conducted to identify group profiles in moral sensitivity among Chinese nursing students and examine the factors associated with moral sensitivity subgroups.

Background: Moral sensitivity is a precondition for ethical decision making. Developing this sensitivity equips nursing students with the skills to identify and respond appropriately to ethical dilemmas, which are essential as they prepare to enter clinical settings.

Negative pressure pulmonary edema following vertebral artery stenting.

Introduction And Importance: Negative pressure pulmonary edema is a rare systemic complication ensuing from general anesthesia.

Case Presentation: In this report, a middle-aged male Who underwent V4 of vertebral artery stenting under general anesthesia, developed acute respiratory distress and a decrease inoxyhemoglobin saturation(SpO2). The condition was controlled after giving high concentration of oxygen assisted ventilation and sputum suction.