Comparison of volatile compounds among different types of Tieguanyin oolong tea using DHI-GC-MS.

Depending on the manufacturing process, Tieguanyin tea (TGY) is classified into three main groups, light flavor type (LFT), heavy flavor type (HFT), and stale flavor type (SFT). However, the compositions and contents of volatile compounds among TGY types were still unclear. This study aimed to develop an efficient method for the nonselective determination of volatile compounds in teas direct-headspace injection coupled with gas chromatography mass spectrometry (DHI-GC-MS), and to perform a comprehensive comparison among these teas.

Safety of edaravone in real-world use: analysis based on FDA adverse event reporting system.

Background: Edaravone is a novel free radical scavenger utilized to treat amyotrophic lateral sclerosis (ALS). However, long-term safety data remain limited.

Research Design And Methods: Adverse event reports related to edaravone from the second quarter of 2017 to the second quarter of 2024 were extracted from the US Food and Drug Administration (FDA) Adverse Event Reporting System database (FAERS).

Continuously Tuning Negative Capacitance via Field-Driven Polar Skyrmions in Ferroelectric Trilayer Wrinkled Films.

Polar topological structures have emerged as a frontier in research due to their significant potential in nanoscale electronic devices. The periodic and ordered arrangement, as well as the dynamic control mechanisms, are essential for their practical applications. Here, we present theoretical phase-field simulations that reveal the periodic and ordered arrangement of skyrmions and in-plane vortices within (SrTiO)/(PbTiO)/(SrTiO) checkerboard-patterned wrinkled trilayer films.

Complex of intratumoral mycobiome and bacteriome predicts the recurrence of laryngeal squamous cell carcinoma.

Unlabelled: Dysbiosis of intratumoral fungal and bacterial communities is associated with poor prognosis in various cancers. However, the mycobiome characteristics in laryngeal squamous cell carcinoma (LSCC) and its correlation with recurrence have not yet been investigated. The mycobiome in 80 LSCC samples was characterized using internal transcribed spacer sequencing, encompassing both tumor tissues and their matched para-cancerous tissues.

Self-Powered Frequency-Selective Acoustic Sensor Based on Bound States in the Continuum.

Sound is a clean, renewable, and abundant energy source present ubiquitously in nature. However, it is often underutilized due to its low energy density in most environments. This study introduces a two-state system that supports a Friedrich-Wintgen bound state in the continuum (BIC), achieving an unprecedented enhancement in sound energy density-up to 1849 times the incident sound intensity.

Effects of Remote Ischemic Conditioning on Postoperative Recovery After Hepatectomy: A Randomised Controlled Trial.

Background And Aims: Remote ischemic conditioning (RIC) has shown promise in preclinical and clinical studies, but its effectiveness in reducing hepatic ischemia-reperfusion injuries (HIRIs) and enhancing postoperative recovery after hepatectomy remains uncertain. In this study, we aimed to evaluate the impact of perioperative RIC (PRIC) on postoperative recovery in patients undergoing hepatectomy.

Methods: A randomised controlled trial was performed.

Leptin Enhances M1 Macrophage Polarization and Impairs Tendon-Bone Healing in Rotator Cuff Repair: A Rat Model.

Background: Rotator cuff tears are common, affecting more than 60% of individuals older than 80 years, and they have been implicated in 70% of patients with shoulder pain. M1 polarization-related inflammation has been reported to be associated with poor healing outcomes of rotator cuff injury, and leptin, an adipokine, has been reported to be a potential activator of inflammation. However, whether leptin affects rotator cuff repair remains unknown.

Enhanced Release and Reactivity of Soil Water-Extractable Organic Matter Following Wildfire in a Subtropical Forest.

Climate-driven increases in wildfire frequency may disrupt soil carbon dynamics, potentially creating positive feedback within global carbon cycle. However, the release and lability of soil carbon following wildfire remain unclear, limiting our ability to predict fire impacts on carbon cycling. Here, we investigated chemical alterations in soil water-extractable organic matter (WEOM) following a subtropical forest wildfire by comparing burned soils to an adjacent unburned site.

Investigating T-Cell Receptor Dynamics Under In Vitro Antibody-Based Stimulation Using Imaging Flow Cytometry.

T cells play a pivotal role in the immune system's response to various conditions. They are activated by antigen-presenting cells (APCs) via T-cell surface receptors, resulting in cytokine production and T-cell proliferation. These interactions occur through the formation of immunological synapses.

Optimal extent of left recurrent laryngeal nerve para-lymph node dissection in esophageal squamous cell carcinoma: a retrospective analysis based on cytokeratin 19 immunopositivity for micrometastasis detection.

No consensus has been achieved for the optimal extent of left recurrent laryngeal nerve para-lymph node dissection (LRLN-LND) for esophageal squamous cell carcinoma (ESCC). Surgeons follow different extents according to their experience, technical proficiency, and habits. Immunohistochemical (IHC) analysis is a feasible method to detect micrometastasis (MM) of lymph nodes in ESCC.

Regional-Specific Decellularized Meniscus Extracellular Matrix Elastic Nanofiber Aerogels Regulate Meniscal Regeneration and Vascularization.

The meniscus is a heterogeneous structure with spatial distribution of cells and vessels. Promoting meniscus healing remains challenging, especially in its avascular inner region. The ideal repair mode shall promote meniscus repair while maintaining local avascularity to prevent pathological changes from vascular invasion.

Effects of fermented wheat germ on the placenta of high-fat diet-induced obese maternal rats: morphology, metabolism, and nutrient transport.

Maternal obesity impairs placental function, affecting fetal growth and long-term health. Although fermented wheat germ (FWG) provides health benefits, its impact on maternal obesity-related metabolic disorders and placental function remains unclear. This study investigated FWG's effects on placental morphology, metabolism, and nutrient transport in high-fat diet (HFD)-induced obese maternal rats.

Bilateral Synergistic Effects of Phototherapy-Based NIR-II Absorption Photosensitizer for Allergic Rhinitis.

Allergic rhinitis (AR) is the most prevalent global health issue, affecting approximately 3 billion people, with its incidence increasing annually. The current first-line pharmacotherapy for symptom relief has limited efficacy and often results in notable side effects. Here, aza-BODIPY-based nanoparticles (RH@NPs) are developed that exhibit mild photothermal therapy (PTT) and type I photodynamic therapy (PDT) capabilities.

SlASR3 mediates crosstalk between auxin and jasmonic acid signaling to regulate trichome formation in tomato.

Trichomes play a pivotal role in plant resistance to biotic and abiotic stresses. Both auxin and jasmonic acid (JA) could induce tomato type II, V, and VI trichome formation. However, the existence of crosstalk between auxin and JA in trichome formation is not yet fully elucidated.

Exosomal miR‑3681‑3p from M2‑polarized macrophages confers cisplatin resistance to gastric cancer cells by targeting MLH1.

Cisplatin (DDP) is a key chemotherapeutic agent in the treatment of gastric cancer; however, its efficacy is often limited by chemoresistance, a notable challenge in clinical oncology. The present study aimed to investigate the influence of exosomes derived from M2‑polarized macrophages, which promote this resistance, on the response of gastric cancer cells to DDP, examining both the effects and the underlying mechanisms. M2 macrophages, differentiated from mouse bone marrow cells with interleukin (IL)‑13 and IL‑4, were identified using immunofluorescence staining for CD206 and CD163.

Hydroxychloroquine: A double‑edged sword (Review).

Hydroxychloroquine (HCQ) is an antimalarial drug that has historically been used to treat and prevent malaria. However, its mechanism of action has not yet been fully elucidated. HCQ affects various cellular and molecular pathways through different mechanisms.

Mechanisms of microplastics on gastrointestinal injury and liver metabolism disorder (Review).

With the high production and use of plastic products, a large amount of microplastics (MPs) is generated by degradation, which causes environmental pollution. MPs are particles with a diameter <5 mm; further degradation of MPs produces nano‑plastics (NPs), which could further increase the damage to cells when entering the human body. Therefore, the present review summarizes the effect of MP and NP deposition on the human gastrointestinal tract and the underlying injury mechanism of oxidative stress, inflammation and apoptosis, as well as the potential mechanism of glucose and liver lipid metabolism disorder.

Generating Self-Adjuvated Nanofiber Vaccines by Coating Bacterial Flagella with Antigens.

Bacteria-based vaccines have received increasing attention given the ability to induce strong systemic immune responses. However, the application of bacteria as therapeutic agents inevitably suffers from infection-associated side effects due to the living characteristics. Here, the use of bacteria-derived flagella is described to construct self-adjuvated nanofiber vaccines.

Industrial-current Ammonia Synthesis by Polarized Cuprous Cyanamide Coupled to Valorization of Glycerol at 4,000 mA cm.

The electrocatalytic nitrate reduction (NORR) holds significance in both NH synthesis and nitrate contamination remediation. However, achieving industrial-scale current and high stability in membrane electrode assembly (MEA) electrolyzer remains challenging due to inherent high full-cell voltage for sluggish NORR and water oxidation. Here, CuNCN with positive surface electrostatic potential V(r) is applied as highly efficient NORR electrocatalysts to achieve industrial-current and low-voltage stable NH production in MEA electrolyzer with coupled anodic glycerol oxidation.

Plant-microbiome interactions and their impacts on plant adaptation to climate change.

Plants have co-evolved with a wide range of microbial communities over hundreds of millions of years, this has drastically influenced their adaptation to biotic and abiotic stress. The rapid development of multi-omics approaches has greatly improved our understanding of the diversity, composition, and functions of plant microbiomes, but how global climate change affects the assembly of plant microbiomes and their roles in regulating host plant adaptation to changing environmental conditions is not fully known. In this review, we summarize recent advancements in the community assembly of plant microbiomes, and their responses to climate change factors such as elevated CO levels, warming, and drought.

Intracellular protein ligation and polyprotein synthesis using an asparaginyl endopeptidase core.

An intracellular protein ligation system using a truncated variant of AEP1 (AEP1 core) to ligate and polymerize Ig domains in is developed, enabling real-time polyprotein synthesis without enzyme activation and external ligation. This approach yields functional, mechanically stable polyproteins and expands AEP applications in synthetic biology and biomaterials.

Engineered Living Memory Microspheroid-Based Archival File System for Random Accessible In Vivo DNA Storage.

Given its exceptional durability and high information density, deoxyribonucleic acid (DNA) has the potential to meet the escalating global demand for data storage if it can be stored efficiently and accessed randomly in exabyte-to-yottabyte-scale databases. Here, this work introduces the Engineered Living Memory Microspheroid (ELMM) as a novel material for DNA data storage, retrieval, and management. This work engineers a plasmid library and devises a random access strategy pairing plasmid function with DNA data in a key-value format.

Arylamine-Linked Porous Organic Polymers with Abundant Redox-Active Sites as High-Capacity and High-Rate Organic Cathodes for Lithium-Ion Batteries.

Redox-active porous organic polymers (POPs) have emerged as promising and sustainable organic cathode materials (OCMs) for lithium-ion batteries (LIBs). However, their performance is significantly limited by insufficient redox-active sites and low intrinsic conductivity. Herein, a series of novel arylamine-linked and bipolar POPs (denoted as HATN-AQ, HATN-BQ, HATN-CBD, and HATN-PTO) are designed and prepared as OCMs for LIBs.

Evaluation of the Efficacy and Safety of Transjugular Intrahepatic Portosystemic Shunt Combined With Concurrent Antegrade Embolization of Large Spontaneous Portosystemic Shunts.

Objectives: To compare the long-term efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) combined with concurrent antegrade embolization in treating portal hypertension with oesophagogastric variceal bleeding in patients with and without large spontaneous portosystemic shunts (L-SPSSs).

Materials And Methods: We retrospectively analysed data from patients with portal hypertension who underwent TIPS from November 2015 to April 2022. The patients were screened according to the inclusion criteria and were divided into L-SPSSs group (L-S group) and Non L-SPSSs group (Non L-S group).