Copper(II) enhances the antibacterial activity of nitroxoline against MRSA by promoting aerobic glycolysis.

Nitroxoline (NIT) is an FDA-approved antibiotic with numerous pharmacological properties. However, the intricate connections between its metal-chelating ability and antimicrobial efficacy remain incompletely understood. The specific interactions of NIT with different metal ions were measured via UV-vis absorption spectroscopy.

Normalization of subendometrial peristalsis in women with a large uterine niche following laparoscopic niche repair: A prospective cohort study.

Objective: To study the impact of laparoscopic niche repair on subendometrial peristalsis in women with a large niche.

Methods: A explorative prospective cohort study that included women with a large niche (residual myometrium ≤ 3 mm), actual wish to conceive who were scheduled for laparoscopic niche repair. To analyse the effect of a laparoscopic niche repair on the uterine anatomy and subendometrial peristalsis, all participants underwent a 4-5 min transvaginal ultrasound before surgery and three months post-surgery during the mid-luteal phase of the menstrual cycle.

Artemisinin analogues are effective in the treatment of psoriasis by targeting RORγt.

Psoriasis is a chronic inflammatory skin autoimmune disease. Th17 cells, when pathologically activated, significantly contribute to the progression of psoriasis. The symptoms of this skin condition could be notably alleviated by targeting and suppressing the activity of these cells.

The safety assessment of ustekinumab on psoriasis and psoriatic arthritis: A real-world analysis based on the FDA adverse event reporting system database.

Objective: To assess safety of ustekinumab (UST) on treatment of patients with psoriasis and psoriatic arthritis (PsA) by analyze UST related adverse drug events (ADEs).

Methods: Data on ADEs associated with UST on psoriasis and PsA were collected from the fourth quarter of 2009 through the third quarter of 2024 in the U.S.

Urolithin A ameliorates schizophrenia-like behaviors and cognitive impairments in female rats by modulating NLRP3 signaling.

The management of cognitive impairments in schizophrenia presents a considerable challenge, with a strong association between neuroinflammation and its progression. Urolithin A (UA) demonstrates important anti-inflammatory properties in multiple neurological disease models, contributing to the enhancement of cognitive deficits. However, it remains uncertain if UA can produce comparable neuroregulatory effects in female rat models of schizophrenia.

Improved neural networks for the classification of microplastics via inferior quality Raman spectra.

Machine learning algorithms are proficient in the rapid extraction of features for the classification of microplastic Raman spectra. Nevertheless, the classification of Raman spectra from microplastics, particularly in the presence of complex environmental interference, remains a substantial challenge. In this study, an improved ResNet model incorporating the Squeeze-and-Excitation (SE) module is employed for the classification and identification of Raman spectra of microplastics across varying quality levels under diverse experimental conditions with insufficient laser power and short spectrum acquisition time.

DECA: harnessing interpretable transformer model for cellular deconvolution of chromatin accessibility profile.

The assay for transposase-accessible chromatin with sequencing (ATAC-seq) identifies chromatin accessibility across the genome, crucial for gene expression regulating. However, bulk ATAC-seq obscures cellular heterogeneity, while single-cell ATAC-seq suffers from issues such as sparsity and costliness. To this end, we introduce DECA, a sophisticated deep learning model based on vision transformer to deconvolve cell type information from bulk chromatin accessibility profiles, utilizing single-cell ATAC-seq datasets as reference for enhanced precision and resolution.

CircDIAPH1 Promotes Liver Metastasis and Development of Colorectal Cancer by Initiation of CEACAM6 Expression.

Liver metastasis is a critical factor influencing the 5-year survival rate in colorectal cancer (CRC). However, the biological function of most circRNAs in liver metastasis of CRC is still unknown. In this study, we identified differentially expressed circRNAs associated with liver metastasis (LM-DE-circRNAs).

Nicotiana benthamiana VASCULAR-RELATED NAC-DOMAIN7-2 (NbVND7-2) has a role in xylem formation during interfamily grafting.

VASCULAR-RELATED NAC-DOMAIN7 (VND7) is a transcription factor gene that plays a critical role in xylem differentiation. The ectopic expression of VND7 induces the formation of secondary cell walls with spiral patterns in multiple plant cell types. In the present study, we have identified four homologs of VND7 in Nicotiana benthamiana and assigned them the names NbVND7-1 to NbVND7-4.

Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study.

Objectives: Previous studies suggested that immune factors may play critical roles in female infertility, but their causal links remain unclear. To address this gap, this study employs the Mendelian randomization (MR) to delineate the causal association between circulating immune factors and female infertility.

Methods: This study employed summary-level data from three genome-wide association studies (GWAS) encompassing 731 peripheral immune cell signatures, 41 circulating cytokines, and five female infertility phenotypes to reveal the causal relationship between immune factors and female infertility.

Identification of metabolite-disease associations based on knowledge graph.

Background: Despite the insights that metabolite analysis can provide into the onset, development, and progression of diseases-thus offering new concepts and methodologies for prevention, diagnosis, and treatment-traditional wet lab experiments are often time-consuming and labor-intensive. Consequently, this study aimed to develop a machine learning model named COM-RAN, which is based on a knowledge graph and random forest algorithm, to identify potential associations between metabolites and diseases.

Methods: Firstly, we integrated the known associations between diseases and metabolites.

PLAGL2-STAU1-NCOA4 axis enhances gastric cancer peritoneal metastasis by resisting ferroptosis via ferritinophagy.

Peritoneal metastasis (PM) is the primary site of distant metastasis in gastric cancer (GC) and is associated with an advanced disease stage and poor prognosis. Due to its high resistance to chemotherapy, disseminated peritoneal lesions are often untreatable. A primary reason for therapy resistance in cancer cells is often their defective cell death execution mechanisms.

The Regulation of TDP-43 Structure and Phase Transitions: A Review.

The transactive response DNA binding protein 43 (TDP-43) is an RNA/DNA-binding protein that is involved in a number of cellular functions, including RNA processing and alternative splicing, RNA transport and translation, and stress granule assembly. It has attracted significant attention for being the primary component of cytoplasmic inclusions in patients with amyotrophic lateral sclerosis or frontotemporal dementia. Mounting evidence suggests that both cytoplasmic aggregation of TDP-43 and loss of nuclear TDP-43 function contribute to TDP-43 pathology.

STING mediates increased self-renewal and lineage skewing in DNMT3A-mutated hematopoietic stem/progenitor cells.

Somatic mutations in DNA methyltransferase 3 A (DNMT3A) are frequently observed in patients with hematological malignancies. Hematopoietic stem/progenitor cells (HSPCs) with mutated DNMT3A demonstrate increased self-renewal activity and skewed lineage differentiation. However, the molecular mechanisms underlying these changes remain largely unexplored.

Insights into the role of hnRNPK in spermatogenesis via the piRNA pathway.

Deletion of hnRNPK in mouse spermatogonia leads to male sterility due to arrest permatogenesis, yet the underlying molecular mechanisms remain elusive. This study investigated the testicular proteome on postnatal day 28 (P28) to elucidate the infertility associated with Hnrnpk deficiency, identifying 791 proteins with altered expression: 256 were upregulated, and 535 were downregulated. Pathway enrichment analysis demonstrated that the downregulated proteins are primarily involved in spermatogenesis, fertilization, and piRNA metabolic processes.

Identification of UBE2N as a biomarker of Alzheimer's disease by combining WGCNA with machine learning algorithms.

Alzheimer's disease (AD) is the most common cause of dementia, emphasizing the critical need for the development of biomarkers that facilitate accurate and objective assessment of disease progression for early detection and intervention to delay its onset. In our study, three AD datasets from the Gene Expression Omnibus (GEO) database were integrated for differential expression analysis, followed by a weighted gene co-expression network analysis (WGCNA), and potential AD biomarkers were screened. Our study identified UBE2N as a promising biomarker for AD.

Glucose Metabolic Reprogramming in Microglia: Implications for Neurodegenerative Diseases and Targeted Therapy.

As intrinsic immune cells in the central nervous system, microglia play a crucial role in maintaining brain homeostasis. Microglia can transition from homeostasis to various responsive states in reaction to different external stimuli, undergoing corresponding alterations in glucose metabolism. In neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), microglial glucose metabolic reprogramming is widespread.

Fokker-Planck diffusion maps of microglial transcriptomes reveal radial differentiation into substates associated with Alzheimer's pathology.

The identification of microglia subtypes is important for understanding the role of innate immunity in neurodegenerative diseases. Current methods of unsupervised cell type identification assume a small noise-to-signal ratio of transcriptome measurements to produce well-separated cell clusters. However, identification of subtypes can be obscured by gene expression noise, which diminishes the distances in transcriptome space between distinct cell types, blurs boundaries, and reduces reproducibility.

Association of inflammatory risk based on the Glasgow Prognostic Score with long-term mortality in patients with cardiovascular disease.

The secondary prevention strategy for cardiovascular disease (CVD) does not include anti-inflammatory treatment, which may lead to long-term inflammation in some patients. The aim of this study was to assess the association between inflammatory risk based on the Glasgow Prognostic Score (GPS) and long-term mortality risk in patients with CVD. This study included 3833 patients (≥ 20 years old) with CVD in the National Health and Nutrition Survey from 1999 to 2010 in the United States.

Universal in situ oxide-based ABX-structured seeds for templating halide perovskite growth in All-perovskite tandems.

Precise control over halide perovskite crystallization is pivotal for realizing efficient solar cells. Here, we introduce a strategy utilizing in-situ-formed oxide-based ABX-structured seeds to regulate perovskite crystallization and growth. Introducing potassium stannate into perovskite precursors triggers a spontaneous reaction with lead iodide, producing potassium iodide and lead stannate.

Profiling of IgG N-glycosylation for axial spondyloarthritis and other rheumatic diseases.

Background: Axial spondyloarthritis (axSpA) is an inflammatory rheumatic disease with challenges in diagnosis and disease activity assessment. While alterations in immunoglobulin G (IgG) N-glycosylation have been observed in varied rheumatic diseases, those in axSpA remains unclear. This study aims to explore the role of IgG N-glycan profiles in diagnosis and disease activity of axSpA.

In-Depth Analysis of Tram Curve Noise Dataset for Rigorous Noise Assessment.

The growth of cities, both socially and economically, has resulted in a higher utilization of trains and high-density mobility. However, this has also led to an escalation of urban environmental issues, specifically pertaining to noise generated by rail operations. The amplified contact between wheels and rails, as well as the vibrations in trains and track structures, contributes to railway noise pollution.

Non-targeted metabolomic profile of Leuconostoc mesenteroides-fermented milk reveals differentially expressed metabolites associated with electro-fermentation.

Background: Leuconostoc mesenteroides (L. mesenteroides) has known as an electrogenic probiotic bacterium. However, metabolites related to electro-fermentation in ferments of L.