Pathways to Sustainable Health Care Development: Study on the Carbon Reduction Potential of Telemedicine in China.

Background: Carbon emissions are a global concern due to their significant greenhouse effect. The health care sector's greenhouse gas (GHG) emissions must be controlled. Telemedicine in China continued to grow between 2020 and 2022, offering a promising solution for reducing carbon emissions in the country's health sector.

Polyhedral Polymeric Microparticles with Interwoven 1 nm Gyroid Pores for Precise Adsorption and Nanoconfined Degradation.

Molecular-scale adsorption, catalysis, and separation demand nanoporous materials with high permeability, extensive surface areas, and pronounced nanoconfined effects. Fabricating polymeric particles with 3-D interwoven pores of ∼1 nm potentially addresses these needs. However, significant challenges remain in controlling their pore interconnectivity, uniformity, and achieving faceted particle shapes.

Ancient genomes reveal trans-Eurasian connections between the European Huns and the Xiongnu Empire.

The Huns appeared in Europe in the 370s, establishing an Empire that reshaped West Eurasian history. Yet until today their origins remain a matter of extensive debate. Traditional theories link them to the Xiongnu, the founders of the first nomadic empire of the Mongolian steppe.

Discovery of Elironrasib (RMC-6291), a Potent and Orally Bioavailable, RAS(ON) G12C-Selective, Covalent Tricomplex Inhibitor for the Treatment of Patients with RAS G12C-Addicted Cancers.

The discovery of elironrasib (RMC-6291) represents a significant breakthrough in targeting the previously deemed undruggable GTP-bound, active KRAS. To target the active state of RAS (RAS(ON)) directly, we have employed an innovative tri-complex inhibitor (TCI) modality involving formation of a complex with an inhibitor, the intracellular chaperone protein CypA, and the target protein KRAS in its GTP-bound form. The resulting tri-complex inhibits oncogenic signaling, inducing tumor regressions across various preclinical models of KRAS mutant human cancers.

Photoinduced Deterministic Polarization Switching in CuInPS for Multifunctional Optoelectronic Logic Gates.

Optoelectronic logic gates (OELGs) converting photonic inputs into electric output based on Boolean logic are promising for next-generation computations, and it is highly desirable to be able to control the current polarity by light for multifunctional devices. Here we report a new strategy for OELGs based on bipolar photoconduction intrinsic to ferroelectric materials, simplifying the device configuration considerably while enabling multiple logic operations. We demonstrate this concept in two-dimensional (2D) ferroelectric CuInPS (CIPS), taking advantage of the fact that its polarization switching is intimately coupled with Cu cation migration, and thus can be deterministically driven by both above- and below-bandgap illumination via the photothermal effect.

Modified Marionette lip-split incision for bucco-gingival cancer.

Selection of incision in anterior bucco-gingival cancer is challenging. Midline vertical incision could lead to lower lip necrosis in cancer surgery due to vascular compromise of labial artery in lesion side. Marionette line incision decreases the risks of lower lip necrosis.

Acute abdominal pain as the initial presenting symptom of pediatric Burkitt lymphoma: A case report and literature review.

Rationale: Acute abdominal pain is a prevalent clinical symptom in pediatric patients, primarily attributed to pediatric acute abdomen. However, there are rare exceptional instances where neoplastic diseases may cause acute abdominal pain.

Patient Concerns: The present study encompasses a case of pediatric Burkitt lymphoma wherein acute abdominal pain manifested as the initial symptom, erroneously diagnosed as acute appendicitis.

Hybrid iterative reconstruction in ultra-low-dose CT for accurate pulmonary nodule assessment: A Phantom study.

This study evaluated hybrid iterative reconstruction in ultra-low-dose computed tomography (ULDCT) for solid pulmonary nodule detection. A 256-slice CT machine operating at 120 kVp imaged a chest phantom with 5 mm nodules. The imaging process involved adjusting low-dose computed tomography (LDCT) settings and conducting 3 ULDCT scans (A-C) with varied minimum and maximum mA settings (10/40 mA).

Association between Blood Trihalomethane Concentrations and the Risk of Dyslipidemia: Nationally Representative Cross-Sectional Study.

Experimental studies have indicated that exposure to disinfection byproducts (DBPs) may affect the lipid synthesis. However, epidemiological evidence is sparse. This study aimed to investigate the relationship between blood trihalomethane (THM) exposure and the risk of dyslipidemia from the National Health and Nutrition Examination Survey 2005-2018.

One-stage Surgery for Intracardiac Leiomyomatosis.

Introduction: Intracardiac leiomyomatosis is a rare, histologically benign, but biologically aggressive tumor developed from uterus. This study aimed to summarize our experience with one-stage surgery for intracardiac leiomyomatosis.

Methods: We retrospectively reviewed seven patients who underwent surgical treatment for intracardiac leiomyomatosis between May 2016 and November 2021.

Characterization of methane microseepage from natural gas reservoirs in mild climate: A case study of Xinchang gas field.

Methane microseepage from oil and gas fields significantly contributes to atmospheric methane level, making it a critical factor in global climate change. Therefore, accurate monitoring of surface flux and investigating migration mechanism are pivotal to evaluating and mitigating the impact of methane microseepage. In this study, methane microseepage from natural gas reservoirs in a mild climate was investigated, using Xinchang gas field as a case study.

Comparative efficacy and safety of dupilumab versus newly approved biologics and JAKi in pediatric atopic dermatitis: A systematic review and network meta-analysis.

Background: The newly approved biologics and Janus kinase inhibitors (JAKi) for pediatric atopic dermatitis (AD) offer additional options for clinical treatment. However, the efficacy and safety differences compared to the first approved biologic, dupilumab, remain unclear. Therefore, a network meta-analysis was conducted to evaluate these differences and identify potentially superior agents.

DNA methylome regulates virulence and metabolism in .

Bacterial pathogens employ epigenetic mechanisms, including DNA methylation, to adapt to environmental changes, and these mechanisms play important roles in various biological processes. is a model phytopathogenic bacterium, but its methylome is less well known than that of other species. In this study, we conducted single-molecule real-time sequencing to profile the DNA methylation landscape in three model pathovars of .

Is MOOC really effective? Exploring the outcomes of MOOC adoption and its influencing factors in a higher educational institution in China.

Massive Open Online Course (MOOC) has gained widespread adoption across diverse educational domains and plays a crucial role in advancing educational equality. Nevertheless, skepticism surrounds the effectiveness of MOOC due to their notably low completion rates. To explore the outcomes of MOOC adoption in higher education and improve its application efficiency, this study compares MOOC with traditional course in terms of mean score and pass rate.

Intelligent tuning method for service scheduling in electric power communication networks based on operational risk and QoS guarantee.

In the operational planning of electric power communication networks, a well-structured service scheduling scheme based on the established network topology can significantly enhance the risk prevention capabilities of these networks. Since routing policies directly influence data transmission paths, routing optimization serves as an effective strategy for improving network performance by mitigating transmission risks and threats. This paper introduces an Intelligent Tuning Method for Service Scheduling in Electric Power Communication Networks Based on Operational Risk and Quality of Service (QoS) Guarantee.

Optimizing Bi-LSTM networks for improved lung cancer detection accuracy.

Lung cancer remains a leading cause of cancer-related deaths worldwide, with low survival rates often attributed to late-stage diagnosis. To address this critical health challenge, researchers have developed computer-aided diagnosis (CAD) systems that rely on feature extraction from medical images. However, accurately identifying the most informative image features for lung cancer detection remains a significant challenge.

GPNMB and ATP6V1A interact to mediate microglia phagocytosis of multiple types of pathological particles.

Pronounced elevation of glycoprotein non-metastatic melanoma B (GPNMB) is a common phenomenon in a variety of brain diseases, but the expression patterns, functions, and molecular signaling of GPNMB have not been well studied. Here, we showed that pathological factors, including neuronal degeneration caused by seizures, caspase-3-induced neuronal apoptosis, neuronal debris, and β-amyloid, induced "on-demand" GPNMB expression in hippocampal microglia. Genetic ablation of GPNMB did not affect acute seizures but worsened chronic epileptogenesis.

Arginine Deprivation Induces Quiescence and Confers Vulnerability to Ferroptosis in Colorectal Cancer.

Metabolic reprogramming is a hallmark of cancer. Rewiring of amino acid metabolic processes provides the basis for amino acid deprivation therapies. In this study, we found that arginine biosynthesis is limited in colorectal cancer (CRC) due to the deficiency of ornithine transcarbamylase (OTC).

Intratumoral Fusobacterium nucleatum Recruits Tumor-Associated Neutrophils to Promote Gastric Cancer Progression and Immune Evasion.

Intratumoral microbiota can impact the development and progression of many types of cancer, including gastric cancer (GC). A better understanding of the precise mechanisms by which microbiota support GC could lead to improved therapeutic approaches. Here, we investigated the effect of intratumoral microbiota on the tumor immune microenvironment (TIME) during GC malignant progression.

Tetramethylpyrazine Nitrone in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

Importance: Tetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS).

Objective: To evaluate the safety and efficacy of orally administered tetramethylpyrazine nitrone in patients with ALS.

Design, Setting, And Participants: This phase 2, multicenter, double-masked, placebo-controlled, randomized clinical trial was conducted from December 24, 2020, through July 14, 2023, in 11 centers in China, with a 180-day follow-up.

Antimicrobial Prophylaxis Use and Outcomes for Children Undergoing Cholecystectomy.

Importance: Consensus guidelines from the Infectious Disease Society of America recommend against antimicrobial prophylaxis in the operative management of uncomplicated cholelithiasis; however, these guidelines were derived entirely from the adult surgical population.

Objective: To compare surgical site infection (SSI) outcomes between children undergoing cholecystectomy who received prophylaxis and those who did not.

Design, Setting, And Participants: This was a cohort study using data from 141 hospitals participating in the National Surgical Quality Improvement Program-Pediatric.

Implantable Dental Barrier Membranes as Regenerative Medicine in Dentistry: A Comprehensive Review.

Background: Periodontitis and bone loss in the maxillofacial and dental areas pose considerable challenges for both functional and aesthetic outcomes. To date, implantable dental barrier membranes, designed to prevent epithelial migration into defects and create a favorable environment for targeted cells, have garnered significant interest from researchers. Consequently, a variety of materials and fabrication methods have been explored in extensive research on regenerative dental barrier membranes.

Correlation Between Relative Peripheral Refraction and Efficacy of Myopia Control After Wearing Multifocal Soft Contact Lenses in Children.

Introduction: This study investigated the relationship between relative peripheral refraction (RPR), retinal choroidal vessel, and the growth rate of axial length (AL) in children with myopia wearing multifocal soft contact lenses (MiSight CLs).

Methods: Forty-four eyes of 44 children with myopia wearing MiSight CLs were included in the study. RPRs and retinal choroidal vessel were measured at baseline, 3 months, 6 months, and 1 year using multispectral refraction topography (MRT) and optical coherence tomography angiograghy (OCTA).

LGENet: disentangle anatomy and pathology features for late gadolinium enhancement image segmentation.

Myocardium scar segmentation is essential for clinical diagnosis and prognosis for cardiac vascular diseases. Late gadolinium enhancement (LGE) imaging technology has been widely utilized to visualize left atrial and ventricular scars. However, automatic scar segmentation remains challenging due to the imbalance between scar and background and the variation in scar sizes.