Preparation of capecitabine-poly(p-dioxanone) electrospraying nanoparticles and influence of particle size on their colorectal cancer inhibitive efficiency.

Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Capecitabine is a chemotherapeutic agent commonly used for the treatment of colon cancer. To realize local sustained release, promote efficient local intracellular transport, and mitigate the systemic toxic effects of capecitabine, a capecitabine prodrug, capecitabine-poly (p-dioxanone) (Cap-PPDO), was successfully synthesized.

Lifei Qingchang Tang attenuates acute lung injury the NF-κB and MAPK signaling pathways.

Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, has antioxidant and anti-inflammatory properties but its mechanism in ALI remains unclear. , LFQCT reduced intracellular Ca, ROS, and NO in LPS-induced RAW 264.

Prognostic Impact of Fluorescent Lymphography on Gastric Cancer After Neoadjuvant Chemotherapy.

Importance: Indocyanine green (ICG)-guided lymphadenectomy has been increasingly used to treat gastric cancer. However, its oncologic impact remains unclear.

Objective: To investigate the effect of ICG tracing on long-term outcomes in patients diagnosed with locally advanced gastric cancer undergoing neoadjuvant chemotherapy (NAC) followed by laparoscopic radical gastrectomy.

Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair.

With the growing interest in skeletal muscle diseases, understanding the processes, factors, and treatments associated with muscle regeneration is crucial. Skeletal muscle regeneration is a complex process that largely depends on the niche composed of cell populations, such as satellite cells, and their microenvironment. Cellular senescence is associated with various physiological processes and age-related diseases and plays a significant role in the muscle regeneration niche.

Breast neurotization along with breast reconstruction after nipple sparing mastectomy enhances quality of life and reduces denervation symptoms in patient reported outcome: a prospective cohort study.

Objective: Persistent postoperative sensory loss significantly limits breast reconstruction following mastectomy. In addition, the absence of sensation profoundly impacts patients' physical well-being and overall quality of life. New surgical techniques involving nerve autograft intercostal nerve elongation have been introduced to neurotize reconstructed breasts.

Beyond-classical computation in quantum simulation.

Quantum computers hold the promise of solving certain problems that lie beyond the reach of conventional computers. Establishing this capability, especially for impactful and meaningful problems, remains a central challenge. Here we show that superconducting quantum annealing processors can rapidly generate samples in close agreement with solutions of the Schrödinger equation.

Green-Solvent-Processed All-Polymer Solar Cells with Enhanced Efficiency and Stability through Molecular Design and Side-Chain Engineering.

Green-solvent-processed all-polymer solar cells (AP-SCs) are regarded as an excellent candidate for renewable energy due to their better stability and eco-friendly features. Two polymers, PYF-U and PYF-BO, have been designed by introducing a Y-series derivative with difluoro-substituted dicyanindenone units and a difluorobenzotriazole derivative as the first and second electron-deficient (A) units, respectively. The introduction of two additional F atoms on dicyanindenone units leads to a more coplanar backbone because of noncovalent interactions.

Negative Enthalpy Doping Stabilizes P2-Type Oxides Cathode for High-Performance Sodium-Ion Batteries.

P2-type NaNiMnO (NNMO) as cathode material for sodium-ion batteries (SIBs) largely suffers from continuous accumulation of local stress caused by destructive structural evolution and irreversible oxygen loss upon cycling, leading to rapid capacity degradation. Herein, a strategy of negative enthalpy doping (NED), wherein transition metal (TM) sites are substituted with 0.01 mol each Sn, Sb, Cu, Ti, Mg, and Zn to increase the stability of the TM layers, is proposed.

10% carbon dioxide improves cognitive function after subarachnoid hemorrhage in rats: inhibiting neuronal apoptosis through the PI3K/AKT signaling pathway.

Many patients experience long-term cognitive dysfunction after subarachnoid hemorrhage (SAH), and effective treatments are currently lacking. Carbon dioxide (CO2), an inexpensive and easily produced gas, forms carbonic acid when dissolved in water. Studies have suggested that hypercapnia may have neuroprotective effects.

Dynamic Bonding for In-Situ Welding of Multilayer Elastomers Enables High-Performance Wearable Electronics for Machine Learning-Assisted Active Rehabilitation.

Patients with hand dysfunction require joint rehabilitation for functional restoration, and wearable electronics can provide physical signals to assess and guide the process. However, most wearable electronics are susceptible to failure under large deformations owing to instability in the layered structure, thereby weakening signal reliability. Herein, an in-situ self-welding strategy that uses dynamic hydrogen bonds at interfaces to integrate conductive elastomer layers into highly robust electronics is proposed.

Photochemistry upon Charge Separation in Triphenylamine Derivatives from fs to μs.

Quantum chemical methods and time-resolved laser spectroscopy are employed to elucidate ultrafast charge-separation processes in triphenylamine (TPA) derivatives upon photoexcitation. When changing the ambient solvent from non-electron-accepting to electron-acceptor solvents, such as chloroform, a vastly extended and multifaceted photochemistry of TPA derivatives is observed. Following initial excitation, two concurrent charge-transfer processes are identified.

Controllable Hydrothermal Synthesis of 1D β-GaO for Solar-Blind Ultraviolet Photodetection.

Gallium oxide (GaO), an ultrawide bandgap semiconductor, is an ideal material for solar-blind photodetectors, but challenges such as low responsivity and response speed persist. In this paper, one-dimensional (1D) GaO nanorods were designed to achieve high photodetection performance due to their effective light absorption and light field confinement. Through modulating source concentration, pH value, temperature, and reaction time, 1D β-GaO nanorods were controllably fabricated using a cost-effective hydrothermal method, followed by post-annealing.

Modified FeO Nanoparticles for Foam Stabilization: Mechanisms and Applications for Enhanced Oil Recovery.

Nanoparticles (NPs) have shown great potential in stabilizing foam for enhanced oil recovery (EOR). However, conventional NPs are difficult to recover and may contaminate produced oil, increasing operational costs. In contrast, superparamagnetic FeO NPs can be efficiently recovered using external magnetic fields, offering a sustainable solution for foam stabilization.

Stretchable, Patterned Carbon Nanotube Array Enhanced by TiCT/Graphene for Electromagnetic Interference Shielding.

Stretchability and flexibility are essential characteristics for high-performance electromagnetic interference (EMI) shielding materials in wearable and smart devices. However, achieving these mechanical properties while also maintaining high EMI shielding effectiveness (SE) for shielding materials remains a significant challenge. Here, a stretchable patterned carbon nanotube (CNT) array composite film, reinforced with two-dimensional (2D) nanomaterials (TiCT and graphene), is fabricated using a straightforward scraping method.

Fluorescence Quenching of Graphene Quantum Dots from Orange Peel for Methyl Orange Detection.

Methyl orange (MO) is an organic synthetic dye widely used in laboratory and industrial applications. In laboratory settings, it serves as an acid-base indicator due to its distinct color change in both acidic and alkaline environments. Industrially, it is primarily utilized in the textile industry for its ultraviolet (UV) absorption properties.

Two-Dimensional Nanomaterials for Polymer-Based Packaging Applications: A Colloidal Perspective.

The integration of two-dimensional (2D) nanomaterials into polymer-based packaging presents a promising avenue for sustainable, high-performance materials. This perspective explores the roles of colloidal interactions in the assembly of 2D materials into thin films for packaging applications. We begin by analyzing the types of colloidal forces present in 2D nanomaterials and their impact on dispersion and stability.

High-Breakdown and Low-Leakage 4H-SiC MOS Capacitor Based on HfO/SiO Stacked Gate Dielectric in Trench Structures.

The progression of SiC MOSFET technology from planar to trench structures requires optimized gate oxide layers within the trench to enhance device performance. In this study, we investigated the interface characteristics of HfO and SiO/HfO gate dielectrics grown by atomic layer deposition (ALD) on SiC trench structures. The trench structure morphology was revealed using scanning electron microscopy (SEM).

TIAM2S Operates Multifaced Talents to Alleviate Radiosensitivity, Restrict Apoptosis, Provoke Cell Propagation, and Escalate Cell Migration for Aggravating Radioresistance-Intensified Cervical Cancer Progression.

Radioresistance remains a major obstacle in cervical cancer treatment, frequently engendering tumor relapse and metastasis. However, the details of its mechanism of action remain largely enigmatic. This study delineates the prospective impacts of short-form human T-cell lymphoma invasion and metastasis 2 (TIAM2S) involving the radiation resistance of cervical cancer.

Atrophic C2C12 Myotubes Activate Inflammatory Response of Macrophages In Vitro.

Background: Skeletal muscle wasting is commonly observed in aging, immobility, and chronic diseases. In pathological conditions, the impairment of skeletal muscle and immune system often occurs simultaneously. Recent studies have highlighted the initiative role of skeletal muscle in interactions with immune cells.

Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma.

Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas, we designed a prospective, phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL. The primary endpoint was the complete remission rate (CRR) at the end of induction (EOI).

Designing Polar Covalent Hybrid Cadmium-Based Chalcohalides Ultraviolet Nonlinear Optical Crystal with Strong Optical Anisotropy via Double-Site Dual FBUs Tailoring.

The pressing demand for both established and innovative technologies to expand laser wavelengths has rendered high-performance nonlinear optical (NLO) crystals with large optical anisotropy indispensable. Here, centrosymmetric [SHC(NH)]CdBr (1) and pseudo-2D layered [SC(NH)]CdBr (2), as well as pseudo-3D noncentrosymmetric [SC(NH)]CdCl (3) are successfully synthesized through the introduction of π-conjugated SC(NH) groups. Compared to ionic compound 1 containing full-halogen coordination tetrahedra, covalent compounds 2 and 3 featuring novel polar [SC(NH)]CdX (X = Br, Cl) tetrahedral units demonstrate enhanced bandgaps (>4 eV) and birefringences (>0.

The Microbiome in Asthma Heterogeneity: The Role of Multi-Omic Investigations.

Asthma is one of the most prevalent and extensively studied chronic respiratory conditions, yet the heterogeneity of asthma remains biologically puzzling. Established factors like exogenous exposures and treatment adherence contribute to variability in asthma risk and clinical outcomes. It is also clear that the endogenous factors of genetics and immune system response patterns play key roles in asthma.

Electroactive Dressing with Selective Sorption of Exudate Enables Treatment of Complicated Wound.

Exudate management and cell activity enhancement are vital to complicated wound healing. However, current exudate management dressings indiscriminately remove exudate, which is detrimental to cell activity enhancement. Herein, a novel class of electroactive bilayer (cMO/PVA) dressing is developed by constructing manganese oxide nanoneedle-clusters decorated commercial carbon cloth (MO), in situ casting polyvinyl alcohol (PVA) hydrogel, and finally charging.

In-device Battery Failure Analysis.

Lithium-ion batteries are indispensable power sources for a wide range of modern electronic devices. However, battery lifespan remains a critical limitation, directly affecting the sustainability and user experience. Conventional battery failure analysis in controlled lab settings may not capture the complex interactions and environmental factors encountered in real-world, in-device operating conditions.

Polyphosphatases have a polyphosphate-independent influence on the virulence of .

an invasive basidiomycete fungal pathogen, causes one of the most prevalent, life-threatening diseases in immunocompromised individuals and accounts for ~19% of AIDS-associated deaths. Therefore, understanding the pathogenesis of and its interactions with the host immune system is critical for developing therapeutics against cryptococcosis. Previous studies demonstrated that cells lacking polyphosphate (polyP), an immunomodulatory polyanionic storage molecule, display altered cell surface architecture but unimpaired virulence in a murine model of cryptococcosis.