Biochemical and toxicity evaluation of Retama sphaerocarpa extracts and in-silico investigation of phenolic compounds as potential inhibitors against HPV16 E6 oncoprotein.

Cervical cancer is a type of cancer which affects the cervix cells. The conventional treatments for cervical cancer including surgery, chemotherapy, and radiotherapy are only effective in premature stages and less effective in late stages of this tumor. Therefore, the therapeutic strategies based on biologically active substances from plants are needed to develop for the treatment of cervical cancer.

Phenolic Compound, Antioxidant, Antibacterial, and In Silico Studies of Extracts from the Aerial Parts of L.

Medicinal plants are considered a major source for discovering novel effective drugs. To our knowledge, no studies have reported the chemical composition and biological activities of Moroccan extracts. In this context, this study aims to characterize the polyphenolic compounds distributed in hydro-methanolic extracts of and evaluate their antioxidant and antibacterial activities; in addition, in silico analysis based on molecular docking and ADMET was performed to predict the antibacterial activity of the identified phenolic compounds.

Evaluation of ACE2 Inhibition by L. and Toxicity Study.

Background: SARS-CoV-2 is a virus that uses ACE2 to enter the host cell.

Aims And Objectives: This study aimed to evaluate the in silico inhibitory activity of polyphenols from Prunus armeniaca (P. armeniaca) on angiotensin-converting enzyme 2 (ACE2).

In-Silico Molecular Modeling Studies to Identify Novel Potential Inhibitors of HPV E6 Protein.

The etiological agent of some anogenital tract cancers is infection with the high-risk human papillomavirus (HPV). Currently, prophylactic vaccines against HPV have been validated, but the presence of drug treatment directed against the infection and its oncogenic effects remain essential. Among the best drug targets, viral oncoprotein E6 has been identified as a key factor in cell immortalization and tumor progression in HPV-positive cells.

Preventive planning against mercury over-exposure among Moroccan dentists using multidimensional statistical methods.

Background: Mercury used in dental amalgams constitutes a significant source of chronic exposure to this heavy metal among dentists. Thus, the safety of dental amalgam remains a controversial issue despite its long history of use. In Morocco, most studies about dental mercury were mainly focused on the environmental risk related to the management of mercury-contaminated waste.

Phytocompounds from as promising anti-Covid-19 drugs: studies and safety assessment.

As an alternative strategy in combating the COVID-19 pandemic, phytoconstituents from medicinal plants are getting attention worldwide. The current investigation focused on the efficacy of the essential phytocompounds identified in to target the main protease (M) of SARS-COV-2 through molecular docking and dynamic analyses; in addition to the safety assessment of this herb . , the 6LU7 structure of M was prepared as a target by Discovery Studio 2020.

Modeling Subjective Symptoms Related to Micro-Hydrargyrism in a Population of Moroccan Dentists.

Background: The ability of mercury to deposit throughout the body and alter a wide range of molecular and cellular pathways results in a polymorphic and complex clinical phenotype with over 250 possible symptoms. However, some of them are recurrently cited as evoking chronic mercury poisoning. In this light, dentists users of dental amalgams are chronically exposed to mercury so that in-depth epidemiological investigations and adapted statistical methods are required to highlight adverse effects of this exposure.