Publications by authors named "Mouhamad Khouja"
Recent studies highlighted genetic aberrations associated with prognosis in Mantle Cell lymphoma (MCL), yet comprehensive testing is not implemented in clinical routine. We conducted a comprehensive genomic characterization of 180 patients from the European MCL network trials by targeted sequencing of peripheral blood DNA using the EuroClonality(EC)-NDC assay. The IGH::CCND1 fusion was identified in 94% of patients, clonal IGH-V-(D)-J rearrangements in all, and 79% had ≥1 somatic gene mutation.
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- * A comprehensive analysis of 97 BCP-LBL cases revealed a mutational profile closely resembling that of BCP-ALL, though with a higher frequency of mutations in epigenetic modifiers in BCP-LBL.
- * The study found that most molecular subtypes from BCP-ALL are also present in BCP-LBL, suggesting that next-generation sequencing can help identify genetic subtypes in BCP-LBL, potentially
Liquid biopsy is a novel diagnostic approach at first developed to characterize the molecular profile of solid tumors by analyzing body fluids. For cancer patients, it represents a noninvasive way to monitor the status of the solid tumor with respect to representative biomarkers. There is growing interest in the utilization of circulating tumor DNA (ctDNA) analysis also in the diagnostic and prognostic fields of lymphomas.
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- Scientists studied how a special protein called gp130 affects liver cells and their immune response to infections.
- They created mice with specific liver cells reacting to gp130 to see how these cells work differently.
- The research found that when liver cells called hepatocytes were activated, they helped the mice fight infections better, but other liver cells didn't show major changes.