Publications by authors named "Mouad Mkamel"
Article Synopsis
- The interaction between PD-1 and PD-L1 is key for tumor immune evasion and represents a target for cancer immunotherapy, though current treatments face issues such as high costs and resistance.
- Benzosampangine emerged from screening 511 natural compounds as a promising PD-L1 inhibitor, exhibiting strong binding affinity compared to existing controls and showcasing unique interactions with key amino acids in the active site.
- ADMET profiling indicates that benzosampangine has advantages over control molecules in terms of solubility, permeability, and low toxicity, supporting its potential use in therapies targeting the PD-1/PD-L1 pathway.
Scorpion envenomation, a grave public health concern, is primarily driven by the potent neurotoxins chlorotoxin and leiurotoxin present in Leiurus species venom. Developing effective treatments is crucial to mitigate its impact. Utilizing a drug-repositioning bioinformatics-based approach, potential inhibitors of these neurotoxins were identified from Food and Drug Administration (FDA)-approved drugs.
View Article and Find Full Text PDFThis study examines the effects of environmental conditions on venom production in four prevalent scorpion species in Morocco: Androctonus amoreuxi, Androctonus mauretanicus, Buthus mardochei, and Scorpio maurus. The research focuses on how climatic factors such as temperature, humidity, and diet-specifically mealworm consumption-affect physical parameters including size and weight, and ultimately venom yield. We conducted a comprehensive investigation involving the capture, acclimatization, and systematic venom extraction from 480 scorpions.
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