TLR4 Blockade Using Docosahexaenoic Acid Restores Vulnerability of Drug-Tolerant Tumor Cells and Prevents Breast Cancer Metastasis and Postsurgical Relapse.

Nonmutational mechanisms were recently discovered leading to reversible drug tolerance. Despite the rapid elimination of a majority of tumor cells, a small subpopulation of "'drug-tolerant"' cells remain viable with lethal drug exposure, which may further lead to resistance or tumor relapse. Several signaling pathways are involved in the local or systemic inflammatory responses contributing to drug-induced phenotypic switch.

A lightweight classification of adaptor proteins using transformer networks.

Background: Adaptor proteins play a key role in intercellular signal transduction, and dysfunctional adaptor proteins result in diseases. Understanding its structure is the first step to tackling the associated conditions, spurring ongoing interest in research into adaptor proteins with bioinformatics and computational biology. Our study aims to introduce a small, new, and superior model for protein classification, pushing the boundaries with new machine learning algorithms.

CTV-Net: Complex-Valued TV-Driven Network With Nested Topology for 3-D SAR Imaging.

The regularization-based approaches offer promise in improving synthetic aperture radar (SAR) imaging quality while reducing system complexity. However, the widely applied l regularization model is hindered by their hypothesis of inherent sparsity, causing unreal estimations of surface-like targets. Inspired by the edge-preserving property of total variation (TV), we propose a new complex-valued TV (CTV)-driven interpretable neural network with nested topology, i.

Multi-modal emotion recognition using EEG and speech signals.

Automatic Emotion Recognition (AER) is critical for naturalistic Human-Machine Interactions (HMI). Emotions can be detected through both external behaviors, e.g.

Decoupling of the Growing Exports in Foreign Trade from the Declining Gross Exports of Embodied Energy.

Transforming the growth mode and realizing green and low-carbon development has been a global consensus and an important governance concept of socialism with Chinese characteristics in the new era. Whether economic growth can be decoupled from carbon emissions and energy consumption is a key indicator for measuring green and low-carbon development and is an inevitable requirement for achieving the goal of carbon neutrality before 2060. Based on the input-output tables for 2002, 2007, 2012, and 2018, this article calculated the embodied energy of export in China's foreign trade and studied the elastic relationship and trend between the growth of foreign trade exports and the total embodied energy of export since China's accession to the WTO.

Timing matters: pre-assembly post-assembly functionalization of a polyoxovanadate-organic cuboid.

The pre-assembly and post-assembly approaches in the functionalization of a polyoxovanadate-organic cuboid, [{VS}(QPTC){V}], are discussed. We have shown that the two pathways have led to distinctly different systems, with either an expanded or contracted interior void space, when phenylphosphonate is introduced at different stages of the self-assembly. One leaves the cuboid framework largely intact, whereas the other results in a compact, twisted cuboid.

In situ gel implant for postsurgical wound management and extended chemoimmunotherapy against breast cancer recurrence.

Postsurgical recurrence of breast cancer is closely related to the inflammatory tumor microenvironment evoked by surgical wounds. Toll-like receptor 4 (TLR4) signaling contributes to NF-κB activation thus secreting various inflammatory cytokines. Herein, we developed an in situ photo-crosslinked hydrogel (D/T gel) concurrently loaded with doxorubicin (DOX) and a TLR4 antagonist, resatorvid (TAK-242).

TPSSI-Net: Fast and Enhanced Two-Path Iterative Network for 3D SAR Sparse Imaging.

The emerging field of combining compressed sensing (CS) and three-dimensional synthetic aperture radar (3D SAR) imaging has shown significant potential to reduce sampling rate and improve image quality. However, the conventional CS-driven algorithms are always limited by huge computational costs and non-trivial tuning of parameters. In this article, to address this problem, we propose a two-path iterative framework dubbed TPSSI-Net for 3D SAR sparse imaging.

How to not build a cage: endohedral functionalization of polyoxometalate-based metal-organic polyhedra.

Introducing functionalities into the interior of metal-organic cage complexes can confer properties and utilities ( catalysis, separation, drug delivery, and guest recognition) that are distinct from those of unfunctionalized cages. Endohedral functionalization of such cage molecules, for decades, has largely relied on modifying their organic linkers to covalently append targeted functional groups to the interior surface. We herein introduce an effective coordination method to bring in functionalities at the metal sites instead, for a set of polyhedral cages where the nodes are formed polyoxovanadate clusters, [V O(OCH)(μ-SO)(COO)].

Ethyl carbamate in Chinese liquor (Baijiu): presence, analysis, formation, and control.

Ethyl carbamate (EC) is a genotoxic and carcinogenic compound that is also a by-product of fermented foods (bread, sour milk, soy cheese, etc.) and alcoholic beverages (wine, sake, distilled liquor, etc.).

Nuclear transformation of Chlamydomonas reinhardtii: A review.

Chlamydomonas reinhardtii is a model organism with three sequenced genomes capable of genetic transformation. C. reinhardtii has the advantages of being low cost, non-toxic, and having a post-translational modification system that ensures the recombinant proteins have the same activity as natural proteins, thus making it a great platform for application in molecular biology and other fields.

Characterization of a novel halotolerant esterase from isolated from salt well mine.

A esterase gene was characterized from a halophilic bacterium which was originally isolated from a salt well mine. Sequence analysis showed that the esterase, named as EstSHJ2, contained active site serine encompassed by a conserved pentapeptide motif (GSSMG). The EstSHJ2 was classified into a new lipase/esterase family by phylogenetic association analysis.

Low-dose paclitaxel via hyaluronan-functionalized bovine serum albumin nanoparticulate assembly for metastatic melanoma treatment.

Due to the critical role of CD44 in mediating cell adhesion and migration, CD44-targeted drug delivery via hyaluronan has been extensively explored. Herein, cationic bovine serum albumin nanoparticles were assembled with hyaluronan (HA) of various molecular weights via simple electrostatic interaction to afford hierarchical nanoparticles (HNPs) with various size distributions and structures. Next, HNPs obtained using 49 kDa HA have been used to encapsulate paclitaxel (PTX-HNPs), which demonstrated selective lung accumulation due to both size effect and CD44-mediated targetability.

A dual receptors-targeting and size-switchable "cluster bomb" co-loading chemotherapeutic and transient receptor potential ankyrin 1 (TRPA-1) inhibitor for treatment of triple negative breast cancer.

Oxidative-stress defense system stands for the vulnerability of tumor cells because of the stronger oxidative stress existing in tumor sites. TRPA-1 has been found to be overexpressed in various tumors, related to the tumor proliferation and metastasis, and promote reactive oxygen species (ROS) and chemotherapy tolerance through Ca-dependent anti-apoptotic pathway in recent studies, which provides a new anti-tumor approach to target oxidative-stress defense system. However, there are few studies on the mechanisms of TRPA-1 inhibition increasing the effectiveness of chemotherapy and inhibiting tumor metastasis.

Hierarchical assembly of hyaluronan coated albumin nanoparticles for pancreatic cancer chemoimmunotherapy.

Pancreatic cancer is a highly malignant carcinoma with limited effective treatment options, resulting in a poor patient survival rate of less than 5%. In this study, cationic albumin nanoparticles were assembled with negatively charged hyaluronic acid (HA) to achieve a hierarchical nanostructure and efficient delivery of small molecule drugs to the tumor site in the pancreas. A combination of chemotherapy with indoleamine-2,3-dioxygenase (IDO) inhibition was explored to enhance the chemotherapeutic efficacy in vivo.

A novel SNP of the Hesx1 gene in bovine and its associations with average daily gain.

As an essential repressor, the homeobox gene Hesx1/HESX1 is required within the anterior neural plate for normal forebrain development. Mutations within the Hesx1 gene have been associated with GH deficiency or combined pituitary hormone deficiency. We detected the polymorphism of Hesx1 gene by PCR-SSCP and DNA sequencing methods in 702 individuals from four Chinese cattle breeds.