Age-related changes in cheek skin movement: A case study of Japanese women.

Background: The majority of conventional studies on skin aging have focused on static conditions. However, in daily life, the facial skin we encounter is constantly in motion due to conversational expressions and changes in facial expressions, causing the skin to alter its position and shape, resulting in a dynamic state. Consequently, it is hypothesized that characteristics of aging not apparent in static conditions may be present in the dynamic state of the skin.

Age-related changes in the fiber structure around adipocytes in the subcutaneous fat layer and their association with skin viscoelasticity.

Objective: Age-related changes in the fiber structure around adipocytes were investigated via scanning electron microscopy (SEM) of excised skin tissues. In addition, the viscoelasticity of the subcutaneous fat layer was evaluated via elastography, and the association between the fiber structure and the viscoelastic properties was assessed.

Methods: Skin tissues excised from the facial cheek area were used.

The effect of observation angles on facial age perceptions: A case study of Japanese women.

Most conventional aging research has limited its approach concerning the head and face shape and skin condition to the frontal face. However, in our daily lives, we observe facial features from various angles, which may reveal or obscure aging features that could only be identified under limited conditions in the past. This study systematically investigates the effect of facial observation angles-specifically, of horizontal and vertical angles-on age impression.

Does age-dynamic movement accelerate facial age impression? Perception of age from facial movement: Studies of Japanese women.

We form impressions of others by observing their constant and dynamically-shifting facial expressions during conversation and other daily life activities. However, conventional aging research has mainly considered the changing characteristics of the skin, such as wrinkles and age-spots, within very limited states of static faces. In order to elucidate the range of aging impressions that we make in daily life, it is necessary to consider the effects of facial movement.

New solution of beauty problem by Staphylococcus hominis: Relevance between skin microbiome and skin condition in healthy subject.

Background/aims: Recently, it was suggested that skin microbiome is related to some skin disease. The possibility of affecting the skin might be high, but there were few reports of the influence on the skin condition in healthy subjects. Our aim was to evaluate the relationship between skin condition and skin microbiome in healthy subjects.

Examination of age-related changes of viscoelasticity in the dermis and subcutaneous fat layer using ultrasound elastography.

Background: Using ultrasound elastography, the present study aimed to measure the viscoelasticity in each skin layer and to determine the relationship between the measured value, age, and body mass index (BMI).

Materials And Methods: The present study included 77 Japanese women. We calculated the BMI and measured the facial cheek via elastography.

Novel Notch-sparing gamma-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library.

Screening of our library of peroxisome proliferator-activated receptor (PPAR) agonists yielded several phenylpropanoic acid-derived gamma-secretase inhibitors (GSIs). Structure-activity relationship studies indicated that (R)-configuration of alpha-substituted phenylpropanoic acid structure and cinnamic acid structure is favorable to prepare Notch-sparing GSIs.