Publications by authors named "Motoki Sekiya"
We present a case of lung carcinoma with a unique biphasic feature. The patient was a 67-year-old male smoker with idiopathic pulmonary fibrosis (IPF). A subpleural tumor in the left lower lobe, embedded in fibrotic tissue, was resected.
View Article and Find Full Text PDFBackground: The cytological features of interstitial pneumonia (IP)-related lung adenocarcinoma (LADC) have not been clearly described. This study aimed to describe its cytomorphological features, uncover potential problems in practical cytological diagnosis, and provide possible solutions.
Methods: Bronchial brushing cytology samples from 40 IP-related LADC cases (the IP group) and 110 control cases (LADC unrelated to IP; the non-IP group) were analyzed.
Background: Multiplex gene-panel tests have recently been developed, including the Oncomine Dx Target Test multi-CDx system (ODxTT), and are commonly used to determine the adaptation of molecular-targeting drugs in non-small cell lung cancer. However, in actual clinical settings, we obtain false results owing to the small biopsy samples. We aimed to optimize tissue preparation methods to improve the success rate.
View Article and Find Full Text PDFArticle Synopsis
- Interstitial pneumonia (IP) is closely linked to the development of lung adenocarcinoma (LADC), particularly in areas of the lung affected by metaplasia in honeycomb lesions.
- The study used a sensitive method called digital droplet polymerase chain reaction (ddPCR) to identify mutations in the metaplastic lung tissue of 13 patients with IP, revealing significantly higher mutation frequencies compared to samples from non-IP patients.
- Specifically, mutations like G12V and G12C were found at higher rates in IP patients, suggesting that these mutations could indicate that bronchiolar metaplasia may serve as a precursor to IP-related LADC.
The present study aimed to elucidate the mechanisms underlying the histogenesis of interstitial pneumonia (IP)-related lung adenocarcinoma (LADC). We focused on the methylation of thyroid transcription factor 1 (). The locus was highly methylated in IP-LADCs compared to non-IP-LADCs.
View Article and Find Full Text PDFPneumocyte injury is a crucial factor influencing the severity of interstitial lung disease (ILD). In this study, we investigated the potential of hepatocyte nuclear factor α (HNF4α) as an immunohistochemical marker to detect pneumocyte injury and as a prognostic marker. Surgical lung biopsy specimens were collected from 309 patients with different types of ILDs (61 idiopathic pulmonary fibrosis (IPF), 173 non-IPF, and 75 unclassifiable ILD).
View Article and Find Full Text PDFAims: Proliferative activity, evaluated from the Ki-67 index, is a strong prognostic factor in lung adenocarcinoma (LADC). Here, we optimised a procedure to measure the Ki-67 index and establish the best cut-off value.
Methods And Results: We examined 342 stage I LADCs for the immunohistochemical expression of Ki-67 using different antibodies, MIB1 and SP6.