Publications by authors named "Motoki Miyakita"
Article Synopsis
- - Melanocortin-4-receptor (Mc4r) is a key receptor that helps manage energy balance by influencing how much food we eat and how much energy we use.
- - A protein called CRTC1, found in brain cells, plays a role in controlling gene activity related to energy management, particularly through the cAMP signaling pathway linked to Mc4r.
- - In experiments, mice lacking CRTC1 in Mc4r-expressing cells showed signs of obesity and metabolic issues, including poorer energy use, indicating that CRTC1 is essential for maintaining proper energy balance in the body.
Melanocortin-4 receptor (MC4R) is a critical regulator of appetite and energy expenditure in rodents and humans. MC4R deficiency causes hyperphagia, reduced energy expenditure, and impaired glucose metabolism. Ligand binding to MC4R activates adenylyl cyclase, resulting in increased levels of intracellular cyclic adenosine monophosphate (cAMP), a secondary messenger that regulates several cellular processes.
View Article and Find Full Text PDFThe melanocortin 4 receptor (MC4R) plays an important role in the regulation of appetite and energy expenditure in humans and rodents. Impairment of MC4R signaling causes severe obesity. MC4R mainly couples to the G-protein G.
View Article and Find Full Text PDFcAMP responsive element binding protein (CREB)-regulated transcription coactivators (CRTCs) regulate gene transcription in response to an increase in intracellular cAMP or Ca2+ levels. To date, three isoforms of CRTC have been identified in mammals. All CRTCs are widely expressed in various regions of the brain.
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