Neuropeptide Y in tiger puffer (Takifugu rubripes): distribution, cloning, characterization, and mRNA expression responses to prandial condition.

Neuropeptide tyrosine (NPY) is a potent orexigenic neuropeptide implicated in feeding regulation in rodents. However, the involvement of NPY in feeding behavior has not well been studied in fish. Therefore, we investigated the role of NPY in food intake using a tiger puffer (Takifugu rubripes) model.

Relationship between alpha-melanocyte-stimulating hormone- and neuropeptide Y-containing neurons in the goldfish hypothalamus.

Intracerebroventricular (ICV) injection of alpha-melanocyte-stimulating hormone (alpha-MSH) inhibits, whereas ICV injection of neuropeptide Y (NPY) stimulates food intake in the goldfish. However, there is little information about the functional relationship between alpha-MSH-induced anorexigenic and NPY-induced orexigenic actions in the goldfish. In this study we examined the relationship between alpha-MSH- and NPY-containing neurons in the goldfish hypothalamus to investigate whether these alpha-MSH- and NPY-containing neurons have direct mutual inputs.

Neuronal relationship between orexin-A- and neuropeptide Y-induced orexigenic actions in goldfish.

Orexin-induced orexigenic action is mediated by neuropeptide Y (NPY) in goldfish and rodents. A previous study indicated that NPY-induced orexigenic action may also be mediated by orexin-A in goldfish. However, there is little information about the mutual actions of orexin-A and NPY in the goldfish.