Publications by authors named "Motoki Fujii"
Article Synopsis
- - A middle-aged woman developed acute compartment syndrome (ACS) in all four extremities after overdosing on multiple medications, including nifedipine and olmesartan, which led to severe swelling and skin necrosis.
- - Her condition required emergency intubation due to haemodynamic instability, and despite initial stabilization, escalating limb swelling was noted, with compartment pressures exceeding 30 mm Hg.
- - The case suggests that the ACS was likely triggered by drug-induced angio-oedema from the medications, highlighting the need for careful monitoring for ACS in patients experiencing significant limb swelling after such overdoses.
Article Synopsis
- Tracheal intubation is commonly performed on critically ill patients, and this meta-analysis explored whether ketamine, due to its favorable cardiovascular effects, reduces mortality during this procedure compared to other agents.
- The research evaluated data from various studies, focusing on mortality rates and other health metrics, finding that ketamine had an 83.2% probability of reducing mortality compared to etomidate, though the difference wasn’t statistically significant.
- Overall, while ketamine is likely safe with comparable outcomes to etomidate based on the data, the absence of significant improvements in secondary outcomes suggests no clear advantage in clinical use beyond standard practice.
We report two the cases of patients with imported Plasmodium falciparum malaria during the COVID-19 pandemic. One was coinfected with COVID-19 and the other was misdiagnosed with COVID-19; either way, the diagnosis of malaria was delayed. These cases suggest that physicians should beware of cognitive biases during pandemics and carefully evaluate febrile patients.
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- Cryptococcosis is a serious fungal infection mainly impacting the lungs and central nervous system, increasingly reported in people without immune deficiencies, like a 55-year-old man with heavy alcohol use.
- Initially mistreated for other conditions, rapid diagnosis was achieved through a multiplex PCR assay of cerebrospinal fluid, leading to timely and effective treatment.
- The specific strain was identified as Cryptococcus neoformans var. grubii using multilocus sequence typing, highlighting the importance of molecular methods alongside newer technologies in accurately diagnosing infections.
Pharmacokinetic and pharmacodynamic considerations in antimicrobial therapy for sepsis.
Expert Opin Drug Metab Toxicol
May 2020
Article Synopsis
- * Key changes in sepsis include increased drug distribution and variable kidney function, making the standard dosing methods ineffective.
- * To optimize treatment, higher initial doses of certain antibiotics should be given, and methods like continuous infusion and drug monitoring are recommended for better outcomes.
Effects of L-histidine and related compounds on protein synthesiswere studied in cultured L6 myotubes. L-Histidine specifically stimulated protein synthesis, whereas D-histidine, histamine, L-arginine and L-lysine did not. Inhibitors of phospholipase A(2), phospholipase C and cyclooxygenase intercepted the stimulatory action of L-histidine on protein synthesis, while inhibitors of protein kinase C and 5-lipoxygenase did not.
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