Publications by authors named "Motoki Akamatsu"
Article Synopsis
- A long-term study on Japanese patients with primary axillary hyperhidrosis evaluated the safety and efficacy of 5% sofpironium bromide gel over 52 weeks, following a brief confirmatory study.
- Out of 185 participants, a majority were female (73%) with a median age of 38; efficacy results showed 57.4% in the switching group and 58.2% in the extension group achieved significant sweat reduction at the end of the study.
- Adverse events were common but generally mild, with application site dermatitis and nasopharyngitis being the most frequent; no serious complications related to the drug were reported.
Article Synopsis
- A phase 3 study tested the effectiveness and safety of 5% sofpironium bromide gel over 6 weeks in Japanese patients with severe underarm sweating (primary axillary hyperhidrosis).
- Out of 281 patients, those using sofpironium showed a 53.9% success rate in meeting the treatment goals compared to 36.4% in the control group, indicating a statistically significant improvement.
- While adverse events occurred in 44.0% of the sofpironium group (mainly mild), serious side effects were not reported, confirming that sofpironium is both effective and relatively safe for treating this condition.
We investigated the efficacy, safety, and clinical significance of trafermin, a recombinant human fibroblast growth factor (rhFGF)-2, for periodontal regeneration in intrabony defects in Phase III trials. Study A, a multicenter, randomized, double-blind, placebo-controlled study, was conducted at 24 centers. Patients with periodontitis with 4-mm and 3-mm or deeper probing pocket depth and intrabony defects, respectively, were included.
View Article and Find Full Text PDFIn animal models, several ubiquitin ligases play an important role in skeletal muscle atrophy caused by unloading. In this study we examined protein ubiquitination and ubiquitin ligase gene expression in quadriceps femoris muscle from healthy volunteers after 20-day bedrest to clarify ubiquitin-dependent proteolysis in human muscles after unloading. During bedrest, thickness and cross-sectional area of the quadriceps femoris muscle decreased significantly by 4.
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