Effect of L-serine on the biosynthesis of aromatic amino acids in Escherichia coli.

It is well known that some amino acids inhibit bacterial growth. L-Serine is known to inhibit the growth of Escherichia coli by inhibition of homoserine dehydrogenase (EC 1.1.

Evaluation of the synergistic adverse effects of concomitant therapy with statins and fibrates on rhabdomyolysis.

Rhabdomyolysis is a severe adverse effect of hypolipidaemic agents such as statins and fibrates. We evaluated this muscular cytotoxicity with an in-vitro culture system. Cellular apoptosis was determined using phase-contrast and fluorescein microscopic observation with Hoechst 33342 staining.