Characterisation of mcr-4.3 in a colistin-resistant Acinetobacter nosocomialis clinical isolate from Cape Town, South Africa.

Objectives: Colistin resistance in Acinetobacter spp. is increasing, resulting in potentially untreatable nosocomial infections. Plasmid-mediated colistin resistance is of particular concern due to its low fitness cost and potential transferability to other bacterial strains and species.

Colistin Resistance Mechanisms in Clinical and spp. Isolates from the Western Cape of South Africa.

Colistin is a last-resort antibiotic for the treatment of carbapenem-resistant Gram-negative infections. Colistin resistance thus poses a threat to human health. Colistin resistance is most commonly encoded by mutations in chromosomal , , , and genes, and the presence of plasmid-mediated genes.

Clonal expansion of colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa.

Objectives: To describe colistin-resistant Acinetobacter baumannii isolates in Cape Town, South Africa.

Methods: A. baumannii isolates identified on Vitek 2 Advanced Expert System were collected from Tygerberg Hospital referral laboratory between 2016 and 2017.

Plasmid-mediated colistin resistance in and clinical isolates from the Western Cape region of South Africa.

Background: Colistin is a last resort antibiotic for the treatment of carbapenem-resistant Gram negative infections. Until recently, mechanisms of colistin resistance were limited to chromosomal mutations which confer a high fitness cost and cannot be transferred between organisms. However, a novel plasmid-mediated colistin resistance mechanism, encoded by the gene, has been identified, and has since been detected worldwide.