Evaluation of rs62527607 [GT] single nucleotide polymorphism located in BAALC gene in children with acute leukemia using mismatch PCR-RFLP.

Acute leukemia is the most common cancer in children and involves several factors that contribute to the development of multidrug resistance and treatment failure. According to our recent studies, the BAALC gene is identified to have high mRNA expression levels in childhood acute lymphoblastic leukemia (ALL) and those with multidrug resistance. Several polymorphisms are associated with the expression of this gene.

mRNA overexpression of : A novel prognostic factor for pediatric acute lymphoblastic leukemia.

is a novel molecular marker in leukemia that is highly expressed in patients with acute leukemia. Increased expression levels of are known as poor prognostic factors in adult acute myeloid and lymphoid leukemia. The purpose of the present study was to evaluate the prognostic significance of the gene expression levels in pediatric acute lymphoblastic leukemia (ALL) and its association with .