Publications by authors named "Mosunmola B Oyeleke"
Purpose: Polycystic ovary syndrome (PCOS) is a complex reproductive event that is delineated by endocrine/metabolic disorders. Alteration of kisspeptin status in the hypothalamus and adipose tissue is critical to increased endocrine/metabolic derangements in PCOS individuals, aggravating the clinical manifestation of PCOS and its complications. Short chain fatty acids (SCFAs) are crucial modulators of metabolic homeostasis.
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- * Three groups of rats were tested: one group received a control, another was given letrozole to induce PCOS, and the third received both letrozole and SPL over 21 days.
- * Results showed that SPL treatment reduced markers of oxidative stress and inflammation, suggesting that SPL may mitigate adipose dysfunction in PCOS by lowering inflammation and preventing cellular damage.
Aims: (BF), an African traditional plant and its species have been widely used as brain tonic for memory enhancement. It has also been reported to help relieve anxiety and some psychological disorders. This study aimed to investigate the mechanisms of action of BF on Amyloid beta (Aβ) 1-42 peptides induced cognitive deficit in male Wistar rats.
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- Bacopa floribunda (BF) is traditionally used in Southwestern Nigeria as a memory enhancer and brain tonic, but there is a lack of scientific research on its effects against dementia.
- The study aimed to evaluate the effects of BF's flavonoids and saponins on dementia, specifically through testing their impact on Alzheimer’s disease-related Amyloid beta (Aβ1-42) in mice.
- Results showed that BF extracts effectively reduced oxidative stress and neuroinflammation caused by Aβ1-42, with higher doses of saponins and flavonoids proving most effective in mitigating these symptoms.
Purpose: Several studies have established impaired testicular function in obese male population, including the young males with childhood obesity, contributing to increased male infertility, which is a universal trend in the last few decades. Short chain fatty acids (SCFAs) have been recently demonstrated to inhibit progression to metabolic comorbidities. The present study therefore hypothesized that SCFAs, acetate attenuates testicular dysfunction in high fat diet (HFD)-induced obese rat model, possibly by modulating Nrf2/PPAR-γ.
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