[Biomechanical properties of the cribriform lamina in glaucoma-induced atrophy of the optic nerve and after decompression operations on the scleral canal].

The authors made a mathematical and clinical analysis of the cribriform lamina (CL) of the optic nerve and nerve fiber bundles passing through its foramens in glaucoma-induced optic neuropathy. It was shown that in elevated intraocular pressure, there was a significant CL deformity leading to the compression and deformity of nerve fibers. The important biomechanical characteristic of CL deformity is the tangent of the angle between the longitudinal axis of the scleral canal and the perpendicular to the CL surface.

[Use of cytostatic therapy with 5-fluorouracil in surgery of glaucoma].

Possibilities, conditions and outlooks of using a 5% fluorouracil solution, as subconjunctival injections after antiglaucomatous interventions and as intraoperative applications in the trabecular area, were studied in 131 patients (143 eyes) with uncompensated developed and advanced glaucoma. The results of clinical examinations showed a high efficiency of using fluorouracil after antiglaucomatous interventions to ensure a long-lasting hypotensive effect. Two injections made in the early postoperative period did not entail any complications and were sufficient to maintain the surgical effect.

[Pathophysiological basis for decompression surgeries and their effect on the optic nerve scleral duct in cases of primary glaucoma].

The visual functions and hemodynamics of the optic-nerve and retina were examined before and after decompression surgeries in the optic nerve. The methods of ophthalmodynamometry and ultrasound dopplerography were used to study the optic-nerve hemodynamics. The results showed an essential improvement in the visual field and blood circulation of the optic nerve in 80.

[Follow up results and pathogenetic substantiation of the effect of decompression surgery on the optic nerve in glaucomatous optic neuropathy].

Retrospective analysis of the efficiency of optic nerve decompression in progressive glaucomatous optic neuropathy in patients with normalized intraocular pressure showed widening and/or stabilization of the visual field in remote periods (6-11 years) in 83.3% patients. Study of the hemodynamics after optic nerve decompression showed a significant improvement of the hemodynamic parameters in the orbital artery-central retinal artery system: increased bloodflow velocity in the central retinal artery, increase of ophthalmic blood pressure and perfusion pressure, dilatation of the arteries, and constriction of veins, which indicates improvement of hemoperfusion in the initial portion of the optic nerve and retina after decompression surgery on the optic nerve.

[Hemodynamics of optic nerve and retina in patients with unstable glaucoma and normal intraocular pressure].

The authors analyze the causes of the progress of glaucomatous atrophy of the optic nerve in normal ophthalmic tone. Ninety-four patients (105 eyes) with different stages of glaucoma were examined; intraocular pressure in them was normalized by drug therapy or surgery. In additional to functional studies, hemodynamics was assessed in all the patients by fluorescent angiography of the optic disk, vacuum ophthalmodynamometry, and ultrasonic dopplerography of the carotid artery, orbital artery, and central retinal artery.

[The late results of a trabeculoretraction operation].

A comprehensive analysis is made of immediate and late results of trabeculoretraction, a new pathogenetically oriented antiglaucoma surgical technique suggested by B. N. Alekseev.

[Decompression operations on the optic nerve in glaucoma].

The authors give theoretical grounds and experimental validation for surgery on the optic nerve to eliminate its atrophic changes in glaucoma. They suggest a technique of the direct intervention at the site of the optic disk, approaching it from the side of the eye cavity. A method for the optic nerve decompression at the site of its stem portion via an extraocular approach is suggested.