Reinforcing β-tricalcium phosphate scaffolds for potential applications in bone tissue engineering: impact of functionalized multi-walled carbon nanotubes.

Beta-tricalcium phosphate (β-TCP) scaffolds manufactured through the foam replication method are widely employed in bone tissue regeneration. The mechanical strength of these scaffolds is a significant challenge, partly due to the rheological properties of the original suspension. Various strategies have been explored to enhance the mechanical properties.

Antioxidant flavonoid-loaded nano-bioactive glass bone paste: apatite formation and flow behavior.

Non-cement pastes in the form of injectable materials have gained considerable attention in non-invasive regenerative medicine. Different osteoconductive bioceramics have been used as the solid phase of these bone pastes. Mesoporous bioactive glass can be used as an alternative bioceramic for paste preparation because of its osteogenic qualities.

Prediction of hamstring tendon autograft diameter using preoperative measurements with different cut-offs between genders.

Purpose: Studies have suggested some predictors for hamstring tendon (HT) autograft diameter based on anthropometric factors and preoperative magnetic resonance imaging (MRI) with variable results. Some authors have attributed the variability to gender differences. This prospective cohort reports the sensitivity and specificity of anthropometric and MRI predictors in males and females separately to determine the difference.

Biomimetic reduced graphene oxide coated collagen scaffold for in situ bone regeneration.

A variety of bone-related diseases and injures and limitations of traditional regeneration methods require new tissue substitutes. Tissue engineering and regeneration combined with nanomedicine can provide different natural or synthetic and combined scaffolds with bone mimicking properties for implantation in the injured area. In this study, we synthesized collagen (Col) and reduced graphene oxide coated collagen (Col-rGO) scaffolds, and we evaluated their in vitro and in vivo effects on bone tissue repair.

Biomechanical Evaluation of Temperature Rising and Applied Force in Controlled Cortical Bone Drilling: an Animal in Vitro Study.

Background: The present study was conducted to quantify the relationships between bone drilling process parameters (i.e., feed rate, resting time, exit rate, and drill bit diameter) and drilling outcome parameters (i.

Relation of the chondromalatia patellae to proximal tibial anatomical parameters, assessed with MRI.

Background Magnetic resonance imaging (MRI) is a non-invasive highly sensitive tool for diagnosing chondromalacia patellae in the early stages. Many studies have evaluated patellar and trochlear morphology with different radiologic indices. We aimed to assess the discriminative power of tibial, patellar, and femoral indices in MRI for chondromalacia patellae.

Mussel-inspired polydopamine induced the osteoinductivity to ice-templating PLGA-gelatin matrix for bone tissue engineering application.

In this study, poly(lactic-co-glycolic acid) (PLGA)-gelatin scaffolds were fabricated using the freeze-casting technique. Polydopamine (PDA) coating was applied on the surface of scaffolds to enhance the hydrophilicity, bioactivity, and cellular behavior of the composite constructs. Further, the synergistic effect of PDA coating and lamellar microstructure of scaffolds was evaluated on the promotion of properties.

Effectiveness of Platelet-ich Plasma Based on Gene Expression in Knee Osteoarthritis.

Background: Intra-articular injection of Platelet-rich plasma (PRP) is an effective method for the treatment of patients with knee osteoarthritis (OA). This study aimed to assess the effects of PRP injection on OA, based on gene expression analysis.

Methods: A sample of 30 subjects with knee OA was asked to complete the Persian versions of the Intermittent and Constant Osteoarthritis Pain (ICOAP) and Knee and Osteoarthritis Outcome Score (KOOS).

Proximal Tibiofibular Joint Inclination Angle and Associated Meniscal Tear in Patients with Discoid Lateral Meniscus.

Discoid lateral meniscus (DLM) is the most common congenital variant of a meniscus with a high prevalence meniscal tear due to abnormal shape and behavior. The proximal tibiofibular joint (PTFJ) has an important role during knee extension and ankle dorsiflexion. The aim of this research is to study the association between PTFJ morphology in MRI and DLM and its pathologies as compared with the normal lateral meniscus in Iranian population.

Transforming growth factor-β3 relation with osteoporosis and osteoporotic fractures.

Background: The high socioeconomic impact of osteoporosis and osteoporotic fracture is due to their high mortality, morbidity, and disease-related costs. Nowadays, bone mineral density (BMD) is a comparatively expensive way to diagnose and follow up patients with osteoporosis. Transforming growth factor-β3 (TGF-β3) is a protein categorized into cytokines.

In vitro and in vivo investigation of PLA/PCL scaffold coated with metformin-loaded gelatin nanocarriers in regeneration of critical-sized bone defects.

Large bone defects constitute a major challenge in bone tissue engineering and usually fail to heal due to the incomplete differentiation of recruited mesenchymal stem cells (MSCs) into osteogenic precursor cells. As previously proposed, metformin (MET) induces differentiation of MSCs into osteoblastic lineages in vitro. We fabricated a Poly (lactic acid) and Polycaprolactone (PLA/PCL) scaffold to deliver metformin loaded gelatin nanocarriers (MET/GNs) to critical-sized calvarial bone defects in a rat model.

Studying the effects of primary arthroplasty on post-treatment results among elderly patients with pertrochanteric fracture.

Various therapeutic methods are available to treat patients with intertrochantric fracture, which is usually caused by falling down. This complication is usually observed among the elderly, particularly old women. The choice of the proper therapeutic method depends on many factors including patient's condition, type of fracture, and the amount of movement.

Comparative impact of systemic delivery of atorvastatin, simvastatin, and lovastatin on bone mineral density of the ovariectomized rats.

Purpose: In addition to lipid-lowering properties, statins have been suggested to affect bone turnover by increasing the osteoblastic bone formation and blocking the osteoclastogenesis. However, there are many controversial reports regarding the beneficial effect of statins on osteoporosis. In this study, we investigated the therapeutic effects of the most important lipophilic statins administered orally for 60 days to the ovariectomized (OVX) female Sprague-Dawley rats and compared the effects on different harvested trabecular and compact bones.

Physicochemical properties and bioactivity of freeze-cast chitosan nanocomposite scaffolds reinforced with bioactive glass.

Chitosan based nanocomposite scaffolds were prepared by freeze casting method through blending constant chitosan concentration with different portions of synthesized bioactive glass nanoparticles (BGNPs). Transmission Electron Microscopy (TEM) image showed that the particles size of bioactive glass (64SiO2.28CaO.

Three-Dimensional Porous Gelapin-Simvastatin Scaffolds Promoted Bone Defect Healing in Rabbits.

Treatment of large bone defects (LBDs) is technically demanding. Tissue engineering is an option. A bioactive graft may be produced by combining tissue scaffolds and healing promotive factors in order to accelerate bone repair.