Publications by authors named "Mostafa Safari"
Article Synopsis
- The study investigated the effects of Melissa officinalis (M. officinalis) extract on depression, anxiety, and sleep quality in type 2 diabetes patients experiencing depressive symptoms.
- In a double-blind clinical trial with 60 participants, those taking 700 mg/day of M. officinalis showed significant reductions in depression and anxiety scores after 12 weeks compared to the control group receiving a placebo.
- Despite improvements in mental health, no significant changes were observed in fasting blood sugar, inflammation markers, sleep quality, or other physical health metrics.
Article Synopsis
- Breast cancer is a leading cause of death among women, making early diagnosis crucial to prevent cancer spread; VEGF is a key growth factor involved in this process.
- Researchers created a citric acid dendrimer linked with a VEGF antagonist peptide, which showed no harm to normal cells but was toxic to cancer cells in lab tests.
- SPECT imaging demonstrated that this dendrimer-anti-VEGF molecule accumulates significantly in tumors, supporting its potential as an effective tool for cancer diagnosis.
Melissa officinalis is a plenteous source of antioxidant flavonols and flavonoids that contain health-promoting and antidiabetic properties, so this study was undertaken to provide the first assessment of the antidiabetic properties of hydroalcoholic extract of M. officinalis in type 2 diabetic patients. We did a randomized, placebo-controlled trial which included 62 patients, receiving either M.
View Article and Find Full Text PDFBackground: The purpose of this study was to investigate the safety and effects of Melissa officinalis, a good source of bioactive components, on apolipoprotein (Apo)B, Apo A-I, and their ratio, lipids ratios and intercellular adhesion molecule-1(ICAM-1) in patients with type 2 diabetes.
Methods: For the present randomized, double-blinded, placebo-controlled clinical trial, 70 type 2 diabetic patients aged 20-65 years old were randomly assigned to receive hydroalcoholic extract of M. officinalis (HEMO) (700 mg/d) or placebo twice-daily for 12 weeks.
In this work, a series of composites of insulin (Ins)/zirconium phosphate (ZrP) were synthesized by intercalation method, then, these composites were coated with TiO by sol-gel method to prepare Ins/ZrP@TiO hybrid composites and the drug release of the composites was investigated by using UV-Vis spectroscopy. Ins/ZrP (10, 30, 60 wt%) composites were prepared by intercalation of insulin into the ZrP layers in water. Then Ins/ZrP composites were coated with different amounts of TiO (30, 50, 100 wt %) by using titanium tetra n-butoxide, as precursor.
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