Publications by authors named "Mostafa S Sherazy"
Inflammation is an important mediator of pathophysiology in bipolar disorder. The omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acid (PUFA) metabolic pathways participate in several inflammatory processes and have been linked through epidemiologic and clinical studies to bipolar disorder and its response to treatment. We review the proposed role of PUFA metabolism in neuroinflammation, modulation of brain PUFA metabolism by antimanic medications in rodent models, and anti-inflammatory pharmacotherapy in bipolar disorder and in major depressive disorder (MDD).
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- Growing evidence suggests that inflammation plays a significant role in the pathology of bipolar disorder, with omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) involved in these inflammatory processes.
- A comprehensive literature search identified 17 relevant studies examining PUFA levels as biomarkers or n-3 PUFA as treatments for bipolar disorder.
- The findings indicate low n-3 PUFA concentrations are associated with symptom severity, and while n-3 PUFA supplementation shows promise in treating mania and depression, results vary across studies, highlighting the need for further research.