Publications by authors named "Mostafa Mostafa Hashim Ellabaan"

In the age of antibiotic resistance and precise microbiome engineering, CRISPR-Cas antimicrobials promise to have a substantial impact on the way we treat diseases in the future. However, the efficacy of these antimicrobials and their mechanisms of resistance remain to be elucidated. We systematically investigated how a target E.

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Antibiotic combinations are considered a relevant strategy to tackle the global antibiotic resistance crisis since they are believed to increase treatment efficacy and reduce resistance evolution (WHO treatment guidelines for drug-resistant tuberculosis: 2016 update.). However, studies of the evolution of bacterial resistance to combination therapy have focused on a limited number of drugs and have provided contradictory results (Lipsitch, Levin BR.

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Article Synopsis
  • Chronic Pseudomonas aeruginosa infections in cystic fibrosis patients are difficult to treat and can lead to high mortality rates.
  • Research shows that this bacteria evolves resistance to antibiotics in predictable ways, resulting in different phenotypic states linked to genetic mutations, particularly in the nfxB gene.
  • Analyzing patient isolates over time reveals that targeting these specific bacterial states with tailored antibiotic treatments can potentially enhance treatment outcomes and combat chronic infections.
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