Publications by authors named "Mostafa K Sedky"
Obesity in the pediatric population is considered a growing problem. It is likely that there will be a significant impact related to obesity on the health of future generations. Obesity has increased the incidence of a spectrum of diseases ranging from microvascular complications over the retina and peripheral nerves to an increased incidence of cancer.
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- - Obesity-related renal changes (ORC) involve impaired kidney function, increased fat buildup, inflammation, and cell death, which can potentially be targeted for treatment.
- - In a study with mice on an obesogenic diet, Dasatinib, a tyrosine kinase inhibitor, was administered to check its effects on various renal markers and structures over 16 weeks.
- - Results showed that Dasatinib improved kidney health by reducing harmful markers related to fat and inflammation, increasing autophagy, and reversing several degenerative changes, suggesting it could be an effective therapy for ORC.