Background: Itch impairs the quality of life for many patients with dermatoses, especially atopic dermatitis (AD), and is frequently induced by a warm environment.
Objective: To determine the mechanism underlying itch induction by warmth, we focused on artemin, a member of glial cell line-derived neurotrophic factors (GDNFs).
Methods: A gene array assay revealed that artemin was expressed in substance P-treated dermal fibroblasts.