Publications by authors named "Mostafa H El Din Moawad"
Background/ Aim: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons, causing progressive atrophy of muscles, hypertonia, and paralysis. This study aimed to evaluate the current evidence and effectiveness of ultrasound in investigating nerve cross-sectional area (CSA) of peripheral nerves, vagus and cervical roots in those with ALS compared with healthy controls and to pool the CSA measurements.
Methods: A systematic search was conducted on Cochrane, Clarivate Web of Science, PubMed, Scopus, and Embase for the mesh terms nerve, ultrasonography, and amyotrophic lateral sclerosis.
Article Synopsis
- Valve-in-Valve (VIV) transcatheter aortic valve replacement (TAVR) shows promise for treating malfunctioning Perceval surgical valves, but data on its effectiveness are limited.
- A study analyzed 57 patients from various reports, with most being women around 76 years old; results showed a reduction in heart gradient and a low complication rate (15.7%).
- VIV-TAVR can be done safely with specific valve technologies, but should only be performed by skilled operators familiar with both TAVR and VIV procedures.*
Dual antiplatelet therapy versus intravenous tissue plasminogen activator with acute minor ischemic stroke: A systematic review and meta-analysis of safety and efficacy.
J Stroke Cerebrovasc Dis
July 2024
Article Synopsis
- This study aimed to compare the safety and effectiveness of Dual Antiplatelet Therapy (DAPT) versus Intravenous Tissue Plasminogen Activator (IV t-PA) for treating minor Acute Ischemic Stroke (AIS).
- A meta-analysis of five studies involving nearly 6,200 patients found no significant differences in treatment efficacy based on modified Rankin scale scores or mortality rates between the two therapies.
- DAPT showed a notably lower risk of bleeding and symptomatic intracranial hemorrhage compared to IV t-PA, suggesting it may be a safer option.
Clinical Characteristics and Prognostic Factors of Endometrial Cancer Patients With Liver Metastasis: A Surveillance, Epidemiology, and End Results Database (SEER)-Based Study of 1,034 Women.
Cureus
February 2024
Background There are several patterns of metastatic spread from endometrial cancer (EC). Although studies have been conducted to study the EC population with distant metastasis in the bone and lungs, there is still a lack of studies on liver metastasis. This study aims to evaluate and assess the clinical features and prognostic factors of EC patients with liver metastasis.
View Article and Find Full Text PDFIntroduction Clinical audits have become essential instruments for evaluating and improving the standard of patient care in healthcare services. While individual clinical audits focus on particular aspects of care, multiple clinical audits across various domains, specialties, or departments provide a more comprehensive understanding of clinical practice and encourage systemic improvements. Methodology This study employed a mixed-methods approach to review and assess various clinical audits and quality improvement initiatives conducted at Al-Karak Governmental Hospital in southern Jordan.
View Article and Find Full Text PDFArticle Synopsis
- Rett syndrome is a rare genetic disorder that mainly affects females, characterized by the loss of skills, communication difficulties, and repetitive hand movements, highlighting the need for effective treatments.
- The study aimed to assess the safety and effectiveness of trofinetide for treating Rett syndrome through Randomized Controlled Trials, analyzing a total of 59 articles and including three eligible studies for in-depth review.
- Results indicated that trofinetide significantly improved behavior and clinical outcomes at a 200 mg dosage, evidenced by better scores on the Rett Syndrome Behavior Questionnaire and Clinical Global Impression-Improvement, although no notable effects were recorded on motor skills or caregiver concerns.