Targeted Adenoviral Vector Demonstrates Enhanced Efficacy for In Vivo Gene Therapy of Uterine Leiomyoma.

Background: Gene therapy is a potentially effective non-surgical approach for the treatment of uterine leiomyoma. We demonstrated that targeted adenovirus vector, Ad-SSTR-RGD-TK/GCV, was highly effective in selectively inducing apoptosis and inhibiting proliferation of human leiomyoma cells in vitro while sparing normal myometrial cells.

Study Design: An in-vivo study, to compare efficacy and safety of modified adenovirus vector Ad-SSTR-RGD-TK/GCV versus untargeted vector for treatment of leiomyoma.

Optimizing vaginal hysterectomy in women with large volume non-prolapse uteri: a novel minimally-invasive "aneurysm needle clampless technique".

To describe and evaluate the safety and feasibility of a new clampless technique using aneurysm needle for vaginal hysterectomy compared with the standard technique as a less minimally-invasive procedure in women with benign large volume non-prolapse uteri.Study design In a pilot study, series of 46 consecutive women with benign large volume (200-500cm(3)) uterine conditions other than pelvic organ prolapse were planned for vaginal hysterectomy (VH). Patients were divided into 2 groups; group-A (21 women): for whom an (aneurysm needle clampless VH) was performed; group-B (25 women): used as a control (standard VH).

"Gestational gigantomastia": a review article and case presentation of a new surgical management option.

Background: Gestational gigantomastia is a nightmare to pregnant women. The currently available surgical intervention is either reduction mammoplasty or simple mastectomy. Reduction mammoplasty carries high risk of recurrence.