Assessing community antibiotic usage and adherence as per standard treatment guidelines: A potential area to enhance awareness at community pharmacy settings.

Background: Antibiotic nonadherence significantly contributes to poor treatment outcomes and antimicrobial resistance. In Southeast Asia, including Bangladesh, community pharmacies are crucial in primary healthcare, and are key sources of over-the-counter antibiotics. However, understanding of adherence to the full course of community-dispensed antibiotics is limited.

Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us?

The current situation with H5N1 highly pathogenic avian influenza virus (HPAI) is causing a worldwide concern due to multiple outbreaks in wild birds, poultry, and mammals. Moreover, multiple zoonotic infections in humans have been reported. Importantly, HPAI H5N1 viruses with genetic markers of adaptation to mammals have been detected.

Replication kinetics, pathogenicity and virus-induced cellular responses of cattle-origin influenza A(H5N1) isolates from Texas, United States.

The host range of HPAIV H5N1 was recently expanded to include ruminants, particularly dairy cattle in the United States (US). Shortly after, human H5N1 infection was reported in a dairy worker in Texas following exposure to infected cattle. Herein, we rescued the cattle-origin influenza A/bovine/Texas/24-029328-02/2024(H5N1, rHPbTX) and A/Texas/37/2024(H5N1, rHPhTX) viruses, identified in dairy cattle and human, respectively, and their low pathogenic forms, rLPbTX and rLPhTX, with monobasic HA cleavage sites.

Development of a policy brief to reform waterpipe tobacco taxation in Egypt.

Background: Waterpipe tobacco smoking is increasing in Egypt, although there are several interventions to reduce its use.

Aim: To describe the development of a policy brief to reform waterpipe tobacco taxation in Egypt.

Methods: During 2019-2022, we synthesized available literature evidence on waterpipe tobacco taxation in Egypt and other countries.

In silico and cheminformatics prediction with experimental validation of an adipogenesis cocktail, sorafenib with rosiglitazone for HCC dedifferentiation.

Purpose: Hepatocellular carcinoma (HCC) resistance to sorafenib treatment and other treatment strategies causes a higher mortality rate in patients diagnosed with HCC.

Research Question: HCC often develops resistance to sorafenib treatment and other therapies, leading to increased mortality rates in diagnosed patients. Herein, we propose a combined therapeutic approach using rosiglitazone, a key factor in cellular differentiation, along with adipogenesis inducers such as dexamethasone, IBMX, and insulin.

Identification of the Novel HLA-DRB3*02:185 Allele by Next-Generation Sequencing in a Post-Transplant Renal Patient.

The novel allele HLA-DRB3*02:185 differs from HLA-DRB3*02:02:01:02 by one nucleotide substitution in codon 191 of exon 4.

An evaluation of the precision of computational methods used in drug development initiatives.

Computational approaches are commonly employed to expedite and provide decision-making for the drug development process. Drug development programs that involve targets without known crystal structures can be quite challenging. In many cases, a viable approach is to generate reliable homology models using the amino acid sequence of the target.

The Novel HLA-DPB1*1327:01 Allele Identified by Next-Generation Sequencing in a Potential Haematopoietic Stem Cell Donor.

The novel allele HLA-DPB1*1327:01 has a non-synonymous mutation difference compared with HLA-DPB1*04:01:01.

Polymorphism in Pseudo-Exon 5 Defines the Novel HLA-DQB1*02:02:01:14 Allele.

The novel allele HLA-DQB1*02:02:01:14 differs from HLA-DQB1*02:02:01:01 by one nucleotide substitution in codon 233 in exon 5.

Printed polylactic acid/akermanite composite scaffolds for bone tissue engineering; development and surface modification.

The susceptibility of bone tissues to various factors such as ageing, accidents, and diseases has led to extensive tissue engineering research focusing on bone tissues. Hence, this research also aims to determine the optimal amount of Akermanite (AK) addition to the polylactic acid scaffold for bone tissue engineering applications, as well as the effects of surface modification on its properties. The Akermanite was synthesized using the sol-gel method.

Deeping Insight of Weakly Solvating Halogen-Free Electrolyte in Enhancing the Electrochemical Performance of Magnesium-Sulfur Batteries.

Magnesium-sulfur (Mg-S) batteries offer a promising energy storage system due to their high theoretical capacity. However, the sluggish conversion reaction kinetics and the shuttle effect of magnesium polysulfides hinder their practical application. The high charge density of the divalent Mg cations leads to slow kinetics caused by significant electrostatic interactions between Mg and its surrounding solvent and anion species.

A survey of Canadian neurologists' perspectives and preferences for laboratory reporting of CSF oligoclonal banding.

Introduction: Cerebrospinal fluid (CSF) oligoclonal banding (OCB) analysis aids in the diagnosis of multiple sclerosis (MS). Despite its clinical importance, there is profound variation in processes, reporting, and interpretation of CSF OCB and associated tests/indices across Canadian laboratories. This is likely due to the lack of clear, evidence-based recommendations on CSF OCB analysis processes and reporting.

Potent neutralization by a RBD antibody with broad specificity for SARS-CoV-2 JN.1 and other variants.

SARS-CoV-2 continues to be a public health burden, driven in-part by its continued antigenic diversification and resulting emergence of new variants. By increasing herd immunity, current vaccines have improved infection outcomes for many. However, prophylactic and treatment interventions that are not compromised by viral evolution of the Spike protein are still needed.

Illuminating bioprocess responses to metal-based nanoparticles addition along hydrogen and methane production pathways: A review.

Recent research has discussed the positive impacts of metal-based nanoparticles (NPs) on bioprocesses producing either hydrogen (H) or methane (CH). The enhancement has been explained by mechanisms such as direct interspecies electron transfer (DIET), metal corrosion, and dissimilatory reduction. Such interactions could induce further benefits, such as controlling oxidation-reduction potential (ORP), mitigating toxicants, promoting enzymatic activity, and altering the microbiome, which have not yet been comprehensively discussed.

Computational challenges and solutions: Prime number generation for enhanced data security.

This paper addresses the computational methods and challenges associated with prime number generation, a critical component in encryption algorithms for ensuring data security. The generation of prime numbers efficiently is a critical challenge in various domains, including cryptography, number theory, and computer science. The quest to find more effective algorithms for prime number generation is driven by the increasing demand for secure communication and data storage and the need for efficient algorithms to solve complex mathematical problems.

Synthesis and investigation of optical properties and enhancement photocatalytic activity of TiO-SnO semiconductor for degradation of organic compounds.

Industrial wastewater treatment using UV irradiation in combination with oxidants or catalysts (TiO) has attracted attention as a promising substitute for conventional methods. Studying the preparation and characterization of TiO-SnO nanocomposites with different ratios, as well as their use in the enhanced photocatalytic degradation of acid red 37 dye in aqueous solution under UV irradiation as a model pollutant, are the goals of the research. The crystalline structures of the prepared nanomaterials were confirmed by XRD and the surface morphology of the samples was studied by TEM.

High-performance human resource practices, organizational identification and employee commitment: the moderating role of organizational culture.

Purpose: Drawing on social exchange and social identity theories, this study examines the mediating role of organizational identification on the relationship between high-performance human resource practices (HPHRPs) and employee commitment. The study further examines the moderating role of organizational culture in this mediated relationship.

Method: A cross-sectional survey was conducted with 340 employees from state-owned enterprises in China, and SPSS was used to test the hypothesized relationships.

Avian influenza A (H5N1) virus in dairy cattle: origin, evolution, and cross-species transmission.

Since the emergence of highly pathogenic avian influenza virus (HPAIV) H5N1 of clade 2.3.4.

Specialized greenness sustainability tools for evaluation of the spectrophotometric methodologies greenness: Spectral signal manipulation for resolving the interfering telmisartan and metoprolol succinate spectra in their bulk and pharmaceutical formulation.

Hypertension is a leading cause of cardiovascular mortality, often accompanied by complications such as arrhythmia and stroke. This silent killer requires a multifaceted pharmacological approach for effective management. This article presents new, environmentally friendly spectrophotometric methods for simultaneous quantification of telmisartan (TER) and metoprolol succinate (MTR) in laboratory prepared mixtures and pharmaceutical formulations.

Genetic Analysis of Heterotaxy in a Consanguineous Cohort.

Heterotaxy (HTX) is a group of clinical conditions with a shared pathology of dislocation of one or more organs along the left-right axis. The etiology of HTX is tremendously heterogeneous spanning environmental factors, chromosomal aberrations, mono/oligogenic variants, and complex inheritance. However, in the vast majority of cases, the etiology of HTX remains elusive.

A Novel Carbon Dot-Bromothymol Blue System for Ratiometric Colorimetric-Fluorometric Sensing of Glutathione in Urine: A Smartphone-Compatible Approach.

This study presents a novel dual-modal approach for glutathione (GSH) detection using blue and yellow dual-emission carbon dots (BY-CDs) and bromothymol blue (BTB) at pH 8.0. The method employs both colorimetric and fluorometric detection modes, offering a new perspective on GSH quantification.

Combination therapy of systemic and local metformin improves imiquimod-induced psoriasis-like lesions with type 2 diabetes: the role of AMPK/KGF/STAT3 axis.

Context: Insulin resistance and a disturbed lipid profile are common associations with type 2 diabetes mellitus (T2DM) and different skin diseases, particularly psoriasis (PsO).

Objectives: We investigated potential therapeutic mechanisms of metformin in a murine animal model of psoriasiform lesions in T2DM.

Materials And Methods: Forty-two rats were randomly divided into control, PsO, and type II DM (T2DM) groups.

Comparison of tracheal diameter in non-brachycephalic versus brachycephalic dogs using manubrium and thoracic inlet tracheal indexes.

Introduction: Narrowed tracheal lumen diameter (TLD) in dogs caused by congenital hypoplasia or acquired tracheal stenosis can result in adverse health effects. Standardized tracheal scores calculated from radiographic measurements have been used to assess tracheal diameter however comparisons have not been made to characterize differences in tracheal lumen among breeds.

Methods: The main objective of this study was to compare tracheal scores at three regions of the trachea among non-brachycephalic dogs, non-bulldog brachycephalic dogs, and bulldogs.