Response of mouse tumor to interferon inducer and radiation.

The antitumor effect of interferon inducer poly(ICLC), given prior to the radiation treatment of Lewis lung carcinoma in C57Bl mice was studied. To induce the tumors, the mice were injected subcutaneously into the hind leg with 3 X 10(4) or 3 X 10(5) tumor cells. The combination treatment consisted of poly(ICLC) given at 1.

Medical radiodiagnosis and pregnancy: evaluation of options when pregnancy status is uncertain.

There are 4 options available to the referring physician in considering radiodiagnostic examinations of patients with uncertain pregnancy status. In the first option, the referring physician in consultation with the radiologist may elect to perform a complete or modified examination, based on a complete evaluation of the risks and benefits of the procedure. Risks, in this case, would include the possibility of irreparable damage to an unsuspected conceptus.

Stability of an injectable disulfiram formulation sterilized by gamma irradiation.

Stability of an injectable disulfiram suspension sterilized by gamma(gamma) irradiation was tested. Single doses of disulfiram powder in plastic syringes were subjected to 50,000 rads of gamma radiation. Culture media were inoculated with the irradiated drug to test for growth of bacteria, fungi, and mycobacteria.

Response of human fibroblasts to low dose rate gamma irradiation.

Cells from 11 human strains, including fibroblasts from patients with the genetic diseases of ataxia telangiectasia (AT), xeroderma pigmentosum (XP), and Fanconi's anemia (FA), were exposed to gamma radiation at high (1.6-2.2 Gy/min) and at low (0.

Quantitative radiation dose-response relationships for normal tissues in man. II. Response of the salivary glands during radiotherapy.

A quantitative dose-response curve for salivary gland function in patients during radiotherapy is presented. Salivary-function data used in this study were obtained from four previously published reports. All patients were treated with 60Co teletherapy to the head and neck using conventional treatment techniques.

Nutritional consequences of the radiotherapy of head and neck cancer.

Nutrition-related complications of radiotherapy were evaluated in 74 head and neck cancer patients. Subjective changes of mouth dryness, taste, dysphagia, appetite, and food preferences were determined by questionnaire before and at weekly intervals during curative radiotherapy. Changes in body weight during therapy were also recorded.

Utility of interferons in clinical radiotherapy.

Interferons are being tested in the treatment of a wide range of malignancies. Clinical experience has indicated that interferons may have relatively few side effects compared to other commonly used antineoplastic agents. In addition, they have shown activity as radiation response modifiers in various experimental systems.

Analysis of risk in computerized tomography and other diagnostic radiology procedures.

Medical practice entails continuous risks to the patient taken in good faith by the physician for the benefit of the patient. Risk of radiation induced cancer death approximates 10(-4) per cGy (rad). Assuming an average whole body dose of 0.

Radiation risks in pregnancy.

A major contraindication of radiodiagnostic procedures is pregnancy. Approximately 1% of all pregnant women are given abdominal x-rays during the first trimester of pregnancy. Evaluation of radiation exposure should involve consideration of the types of examinations performed and when performed, as well as radiation dose and risk estimation.

Long-term effects of radiotherapy on taste and salivary function in man.

The long-term effects of radiotherapy on taste and salivary function were studied in 13 patients treated by radiation 1--7 years previously for tumors of the head and neck. Taste function was quantitatively evaluated using a standard forced choice, three-stimulus-drop technique for the determination of detection and recognition thresholds and a forced-scaling technique for the determination of taste intensity responsiveness. Parotid salivary function was quantitatively evaluated by determination of flow rate and protein secretion rate.

Potentiation of radiation injury by interferon.

Interferon (IFN) is being tested clinically in the treatment of a wide range of human malignancies. Patients undergoing cancer treatment may require radiotherapy in conjunction with IFN administration. This study examined the effect of purified preparations of IFN on the radiation response of mouse Swiss 3T3 cells in culture.

Accidental beta radiation burns from an electron accelerator.

A 61-year-old man presented to the emergency department after accidental exposure to beta radiation and low dose x radiation from an industrial linear electron accelerator. Over 40 days he developed burns on the extremities, abdomen, and face which eventually healed with topical silver sulfadiazine treatment, but suffered no acute x or gamma radiation symptoms. Beta burns and other radiation effects are discussed.