6-Methoxylated Flavonoids: Jacein, and 3-demethyljacein from with Their Endoplasmic Reticulum Stress and Apoptotic Cell Death in Breast Cancer Cells Along with Analysis.

In phytochemical analysis, Jacein derivatives: 5,7,4'-trihydroxy-3,6,3'-trimethoxyflavone-7(β)-D-glucopyranoside (), and 3-demethyljacein: 3,5,7,4'-tetrahydroxy-6,3'-dimethoxyflavone-7(β)-D-glucopyranoside () were isolated from for the first time. The structures were determined by interpretation of NMR, UV, and Mass spectra. To check the roles of ER stress and consequent apoptosis in MCF-7 cell by these compounds, UPR signaling pathway was further examined by analysis of expression of ER stress-related genes.