New nano-complexes targeting protein 3S7S in breast cancer and protein 4OO6 in liver cancer investigated in cell line.

Cancer, a lethal ailment, possesses a multitude of therapeutic alternatives to combat its presence, metal complexes have emerged as significant classes of medicinal compounds, exhibiting considerable biological efficacy, especially as anticancer agents. The utilization of cis-platin in the treatment of various cancer types, including breast cancer, has served as inspiration to devise novel nanostructured metal complexes for breast cancer therapy. Notably, homo- and hetero-octahedral bimetallic complexes of an innovative multifunctional ether ligand (comprising Mn(II), Ni(II), Cu(II), Zn(II), Hg(II), and Ag(I) ions) have been synthesized.

Stem Cell Markers (Cytokeratin 17 and Cytokeratin 19) in Scarring and Nonscarring Alopecia.

Background: Alopecia is one of the most important hair follicle (HF) disorders, which is divided into scarring (cicatricial) and nonscarring (noncicatricial) types.

Objective: The aim of this study is to investigate the expression of stem cell (SC) markers such as cytokeratin (CK) 17 and CK19 in scarring and nonscarring alopecia.

Materials And Methods: Thirty patients with scalp alopecia (15 with scarring alopecia and 15 without) together with ten healthy volunteers were included in this study.

Evaluation of the Role of Granzyme B in Exuberant Scar Pathogenesis: An Immunohistochemical Study.

Objective: To evaluate the possible role of Granzyme B (GzmB) in abnormal wound healing through its immunohistochemical expression in keloid and hypertrophic scars and to study the relationship of its expression with the clinicopathologic parameters of studied cases.

Study Design: Using immunohistochemical techniques, GzmB was analyzed in skin biopsies of 44 patients (30 cases with abnormal scars [21 with keloid and 9 with hypertrophic scars] and 14 age- and gender-matched cases with surgical scars as a control group).

Results: GzmB was expressed in keratinocytes in 28.

Leukemia cutis from CD56 positive, myeloperoxidase negative acute myeloid leukemia.

Acute myeloid leukemia (AML) is a clonal expansion of myeloid blasts in peripheral blood, bone marrow, or other tissues. Cutaneous manifestations of leukemia are either specific or nonspecific. Specific lesions result from direct infiltration of the skin by leukemic cells.

Vitiligo: is it grace or curse?

Vitiligo is a common skin disease, affecting approximately 0.5% of the general population. It is characterized by milky white macules and patches, which are a psychological burden to many patients.

Expression of matrix metalloproteinase-2 in renal cell carcinoma.

Background: Renal cell carcinoma (RCC) is a family of carcinomas arising from the renal tubular epithelium through different genetic lesions. The most common characterstics of RCC are hypervascularity, tendency to metastasize widely before giving rise to any symptoms or signs, and poor prognosis. It has been reported that matrix metallopropteinases (MMPs) are a family of endopeptidases implicated in tissue remodeling and cancer invasion.