Glioblastoma multiforme (GBM) is a malignant primary type of brain cancer with high proliferation and metastasis rates due to involvement of the microglial cell. It is resistant against available chemotherapy. Many strategic protocols have been developed but prognosis and patient life has not improved substantially.
View Article and Find Full Text PDFAfrica is rich in a wide range of flora that are exploited as herbal medicines and remedies. Several diseases such as diabetes, diarrhea, dysentery and jaundice have been successfully managed using herbal medicines. Herbal decoctions or concoctions have been used as pain killers, antibiotics, and hematinics.
View Article and Find Full Text PDFThe antiproliferative effect of the fatty acid components of Clerodendrum volubile leaves as well as its antioxidant effect on MCF-7 and MDA-MB-231 human breast cancer cell lines were investigated. Fatty acids extracted from C. volubile leaf oil were subjected to gas chromatography mass spectrometry (GCMS) analysis.
View Article and Find Full Text PDFThe search for novel drugs and alternative medicine has led to increased research in medicinal plants. Among such plants is the orange fruit. Its peels have been utilized for long as an active ingredient in most traditional medicines.
View Article and Find Full Text PDFThe hypoglycemic activities of nine sub-fractions from the methanolic leaf crude extract of Anisopus mannii were investigated in normoglycemic and alloxan-induced diabetic mice. The methanolic sub-fraction M at 400 mg/kg bw showed significantly (p<0.05) high reduction in fasting blood glucose (FBG) at 27.
View Article and Find Full Text PDFJ Complement Integr Med
January 2011
The objective of this paper was to investigate the phytochemistry and hypoglycemic activities of aqueous extracts of Anisopus mannii, Daniella olivieri, Detarium macrocarpum, Leptedenia hastate and Mimosa invisa, traditionally prescribed for diabetes mellitus. The aqueous extracts were tested for phytochemicals and free radical scavenging activity by the DPPH assay. The antidiabetic tests were performed in normoglycemic and alloxan induced diabetic mice.
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