Publications by authors named "Moses Mosobo Kortok"
Article Synopsis
- Early identification of genetic variants linked to antimalarial drug resistance can help improve public health strategies by targeting timely interventions.* -
- Researchers analyzed over 75,000 high-quality genetic variants from 27 Plasmodium falciparum isolates, discovering important associations with dihydroartemisinin resistance on chromosome 13 and in specific candidate genes on chromosomes 1 and others.* -
- The study highlights the effectiveness of whole-genome sequencing in revealing genetic factors that influence parasitic sensitivity to treatments, offering valuable insights for understanding resistant infections.*
To gain insight into why antibody responses to malarial antigens tend to be short lived, we studied antigen-specific memory B cells from donors in an area where malaria is endemic. We compared antibody and memory B cell responses to tetanus toxoid with those to 3 Plasmodium falciparum candidate vaccine antigens: the C-terminal portion of merozoite surface protein 1 (MSP1(19)), apical membrane antigen 1 (AMA1), and the cysteine-rich interdomain region 1 alpha (CIDR1 alpha ) of a protein from the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family.
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