The Readability, Understandability, and Suitability of Online Resources for Ostomy Care.

Purpose: the purpose of this study was to evaluate the content, readability, understandability, and suitability of online resources for patient specific ostomy care.

Design: Retrospective cohort study.

Subject And Setting: Online websites for ostomy care designed for patients.

Vanillic acid ameliorates diethyl phthalate and bisphenol S-induced oxidative stress and neuroinflammation in the hippocampus of experimental rats.

Long-term adverse effects on human health are caused by exogenous compounds that alter the functions of biological systems, especially neuroendocrine disruptors like diethyl phthalate (DEP) and bisphenol S (BPS). Although vanillic acid (VA) has pertinent neuropharmacological characteristics, its effect against DEP + BPS-induced neurotoxicity has not been explored. This study proposed that VA may offer protection against the neurotoxicity caused by DEP + BPS.

The mental health of staff at violence against women organizations during the COVID-19 pandemic: Findings from a mixed-methods study of service providers in Canada's largest city.

Objectives: Staff at violence against women (VAW) organizations provide essential services for survivors of violence. The increase in VAW during the COVID-19 pandemic placed additional pressures on VAW staff. We investigated the impacts of the pandemic on the mental health of VAW staff in the Greater Toronto Area to inform recommendations for policy and practice.

Effect of clinical engagement on value, standardisation, decision-making and savings in NHS product procurement.

Background: UK healthcare expenditure is now £193.8 billion a year. The procurement function is seen as central to driving efficiencies within the NHS.

Historical Mortality Dynamics on the Baja California Peninsula : Marriage, Mining Booms, Migration, and Infectious Disease.

Historical demographic research shows that the factors influencing mortality risk are labile across time and space. This is particularly true for datasets that span societal transitions. Here, we seek to understand how marriage, migration, and the local economy influenced mortality dynamics in a rapidly changing environment characterized by high in-migration and male-biased sex ratios.

Less Is More: Parathyroidectomy and Association with Postoperative Hypocalcemia in Dialysis Patients.

Background: Parathyroidectomy (PTx) is the most effective treatment for secondary hyperparathyroidism. Literature regarding the effect of surgical approaches on postoperative hypocalcemia is limited and mainly focuses on postoperative calcium levels. This study aims to evaluate the association of subtotal PTx and total PTx with autotransplantation for secondary hyperparathyroidism with postoperative hypocalcemia.

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.

Deregulated de novo lipid synthesis (DNLS) is a potential druggable vulnerability in glioblastoma (GBM), a highly lethal and incurable cancer. Yet the molecular mechanisms that determine susceptibility to DNLS-targeted therapies remain unknown, and the lack of brain-penetrant inhibitors of DNLS has prevented their clinical evaluation as GBM therapeutics. Here, we report that YTX-7739, a clinical-stage inhibitor of stearoyl CoA desaturase (SCD), triggers lipotoxicity in patient-derived GBM stem-like cells (GSCs) and inhibits fatty acid desaturation in GSCs orthotopically implanted in mice.

Recommendations for Canada's National Action Plan to End Gender-Based Violence: perspectives from leaders, service providers and survivors in Canada's largest city during the COVID-19 pandemic.

Introduction: The Canadian government has committed to a national action plan (NAP) to address violence against women (VAW). However, a formalized plan for implementation has not been published. Building on existing recommendations and consultations, we conducted the first formal and peer-reviewed qualitative analysis of the perspectives of leaders, service providers and survivors on what should be considered in Canada's NAP on VAW.

Levetiracetam-associated behavioral adverse events in neurocritical care patients.

Study Objectives: The objective of this study was to identify the incidence of levetiracetam-associated BAEs in NCC patients.

Design: Single-center retrospective cohort analysis.

Data Source: Patient charts.

The voice of stoma care nurses: an exploration of stoma care in England.

Background: This article is part two of a series presenting the findings of stakeholder surveys with ostomates and stoma care nurses (SCNs) for stoma services in England. Part one explored the experiences of ostomates. This article focuses on the views and experiences of 108 SCNs in England.

Punitive school discipline as a mechanism of structural marginalization with implications for health inequity: A systematic review of quantitative studies in the health and social sciences literature.

Punitive school discipline deploys surveillance, exclusion, and corporal punishment to deter or account for perceived student misbehavior. Yet, education and legal scholarship suggests it fails to achieve stated goals and exacerbates harm. Furthermore, it is disproportionately imposed upon Black, Latinx, Native/Indigenous, LGBTQIA, and disabled students, concentrating its harms among marginalized young people.

Coastal Erosion and Flood Coping Mechanisms in Southern Thailand: A Qualitative Study.

Communities in coastal regions are affected by the impacts of extreme climatic events causing flooding and erosion. Reducing the impacts of flood and erosion in these areas by adopting coping strategies that fortify the resilience of individuals and their localities is desirable. This study used summative content analysis to explore the coping mechanisms of coastal communities before, during, and after various dangers relating to flooding and erosion.

The voice of ostomates: an exploration of stoma care in England.

Background: This article is part one of a series presenting the findings of stakeholder surveys with ostomates and stoma care nurses for stoma services in England. Due to the volume of data and publication limits this article focuses on the views and experiences of 2504 people living with a stoma (ostomates).

Aim: To understand the experience of ostomates in relation to the current services provided in hospital and at home, the delivery of care and views on areas that work well and areas that require improvement.

Coastal dynamism in Southern Thailand: An application of the CoastSat toolkit.

In Thailand, 17% of the population lives by the coast, approximately 11 million people. A combination of coastal erosion, sea level rise and coastal land subsidence are critical issues threatening the livelihoods of coastal communities. Thailand has invested a lot of money and installed conservation policies to restore and protect coastal mangroves and realign or replenish their beaches.

Morin Augmented Myocardial eNOS/cGMP/PKG Signaling Pathway and Abated Oxidative and Inflammo-apoptotic Responses in Diethyl Phthalate and Bisphenol-S Co-Exposed Male Albino Rats.

Cardiac failure accounts for many deaths worldwide. Increasing experimental evidence suggests that exposure to chemicals such as bisphenol-S (BPS) and diethyl phthalate (DEP) exacerbate cardiac injuries. Morin is a flavonoid with reported cardioprotective activity.

Socio-Economic Resilience to Floods in Coastal Areas of Thailand.

Krabi and Nakhon Si Thammarat are two coastal provinces in Thailand facing substantial threats from climate change induced hydrometeorological hazards, including enhanced coastal erosion and flooding. Human populations and livelihoods in these coastal provinces are at greater risk than those in inland provinces. However, little is known about the communities' resilience and coping capacities regarding hydrometeorological hazards of varying magnitudes.

Identifying critical DO with compensatory reserve during simulated hemorrhage in humans.

Background: Based on previous experiments in nonhuman primates, we hypothesized that DO crit in humans is 5-6 ml O ·kg  min .

Study Design And Methods: We measured the compensatory reserve (CRM) and calculated oxygen delivery (DO ) in 166 healthy, normotensive, nonsmoking subjects (97 males, 69 females) during progressive central hypovolemia induced by lower body negative pressure as a model of ongoing hemorrhage. Subjects were classified as having either high tolerance (HT; N = 111) or low tolerance (LT; N = 55) to central hypovolemia.

A hidden layer of structural variation in transposable elements reveals potential genetic modifiers in human disease-risk loci.

Genome-wide association studies (GWAS) have been highly informative in discovering disease-associated loci but are not designed to capture all structural variations in the human genome. Using long-read sequencing data, we discovered widespread structural variation within SINE-VNTR- (SVA) elements, a class of great ape-specific transposable elements with gene-regulatory roles, which represents a major source of structural variability in the human population. We highlight the presence of structurally variable SVAs (SV-SVAs) in neurological disease-associated loci, and we further associate SV-SVAs to disease-associated SNPs and differential gene expression using luciferase assays and expression quantitative trait loci data.

Interactions Between Opioids and Dextroamphetamine on Locomotor Activity: Influence of an Opioid's Relative Efficacy at the Mu Receptor.

Opioids and stimulants are often used in combination for both recreational and non-recreational purposes. High-efficacy mu opioid agonists generally increase the behavioral effects of stimulants, whereas opioid receptor antagonists generally attenuate the behavioral effects of stimulants; however, less is known regarding the interactions between stimulants and opioids possessing low to intermediate efficacy at the mu receptor. The purpose of this study was to examine the role of an opioid's relative efficacy at the mu receptor in altering the behavioral effects of dextro(-)amphetamine.

Meta-inhibition of ocular and gastrointestinal dysfunctions by phenolic-rich fraction of leaves in a rat model exposed to chronic mixed metals.

Purpose: This study was aimed at investigating the protective effect of antioxidant-rich fraction of (C-ZAMB) leaves on ocular-gastrointestinal dysfunction in rats exposed to environmental mixed-metal (EOMABRSL).

Materials And Methods: The rats were divided into five ( = 10) groups. Group I designates the control which received 0.

Testing the Contribution of Multi-Source Remote Sensing Features for Random Forest Classification of the Greater Amanzule Tropical Peatland.

Tropical peatlands such as Ghana's Greater Amanzule peatland are highly valuable ecosystems and under great pressure from anthropogenic land use activities. Accurate measurement of their occurrence and extent is required to facilitate sustainable management. A key challenge, however, is the high cloud cover in the tropics that limits optical remote sensing data acquisition.