Publications by authors named "Moses Agwaya"
Article Synopsis
- Osteoporosis is a widespread condition, and this study examined the potential anti-osteoporosis effects and phytochemical profile of P. africana stem bark extracts using mouse bone marrow macrophages and zebrafish larvae.
- The experiments found that the methanolic extracts of P. africana significantly inhibited osteoclast activity (TRAP) and the production of inflammatory markers like Nitric Oxide (NO) and Interleukin-6 (IL-6) while also showing promising cell viability.
- The research highlighted several bioactive compounds in the extracts with anti-osteoporosis potential and noted no signs of liver toxicity in the zebrafish larvae tested.
Root Extract of a Micropropagated Medicinal Plant Induced Apoptosis in Human Prostate Cancer Cells (PC-3) via Caspase-3 Activation.
Evid Based Complement Alternat Med
January 2022
Article Synopsis
- * A study evaluated the cytotoxic effects of ethanolic root extracts from micropropagated plants on PC-3 prostate cancer cells, comparing them to traditional stem-bark extracts.
- * Results showed that both extracts had dose-dependent anti-cancer effects, with the root extracts showing potential as an alternative treatment, which may also help preserve endangered plant species.
Antiosteoporosis Activity and Hepatotoxicity Evaluation in Zebrafish Larvae of Bark Extracts of Medicinal Plant.
Evid Based Complement Alternat Med
September 2020
Article Synopsis
- Osteoporosis is a major global health issue linked to weakened bones, prompting increased research into natural treatments, including various bark extracts.* -
- This study assessed the antiosteoporosis effects and potential liver toxicity of these extracts by examining their impact on mouse bone cells and nitric oxide production in specific cell lines.* -
- Results showed that the bark extracts significantly reduced harmful TRAP activity in bone cells and did not cause liver damage in zebrafish larvae, indicating potential for future osteoporosis drug development.*
Background: Medicinal plants offer cheaper and safer treatment options to current diabetic drugs. The present study evaluated the effect of aqueous root bark extract of Zanthoxylum chalybeum on oral glucose tolerance and pancreas histopathology in alloxanized rats.
Method: Diabetes was induced in rats by administration of alloxan monohydrate.
Introduction: Artemisia annua plant from the family Asteracea is a powerful antimalarial plant introduced to Uganda around 2003. In addition to the artemisinin component, the plant also contains flavonoids which work in synergy to artemisinin against malaria parasites. The plant also contains aromatic oils which repel mosquitoes.
View Article and Find Full Text PDFPreclinical efficacy and safety of herbal formulation for management of wounds.
Afr Health Sci
September 2011
Background: Medicinal plants in Uganda and other developing countries have been scientifically demonstrated to have medicinal benefits but few or none have been translated to products for clinical use. Most herbal products developed by local herbalists and sold to the public are not standardized and lack efficacy and safety data to support use.
Objective: To formulate from two Ugandan medicinal plants a herbal product for wound management and test its preclinical safety and efficacy using rat models.