Publications by authors named "Morton Smith"
Purpose Of Review: To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss.
Recent Findings: Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies exist long before the development of clinically visible retinopathy. Such diagnostics could facilitate risk stratification and selective early intervention in high-risk patients.
Purpose: To examine whether herpes zoster antigen (also called varicella-zoster virus antigen) was detectable in temporal artery biopsies taken from individuals with giant cell arteritis (GCA).
Design: Retrospective comparative case series.
Methods: Sections of formalin-fixed paraffin-embedded temporal arteries were examined first by hematoxylin-eosin (H&E) staining to establish the diagnosis of GCA.
Purpose: This study evaluates the prognostic performance of a 15 gene expression profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic subgroups: class 1 (low metastatic risk) and class 2 (high metastatic risk).
Design: Prospective, multicenter study.
Participants: A total of 459 patients with posterior uveal melanoma were enrolled from 12 independent centers.
Purpose: To present the histologic and immunohistochemical findings of an epiretinal membrane overlying a combined hamartoma of the retina and retinal pigment epithelium.
Methods: An interventional case report.
Results: A 17-year-old healthy girl with a history of congenital cataract presented with a combined hamartoma of the retina and retinal pigment epithelium with prominent epiretinal membrane portion.
Purpose: To describe characteristic histopathologic markers in deep anterior lamellar keratoplasty (DALK) using pneumatic dissection: Anwar "big-bubble" technique.
Methods: Case reports. Deep stromal buttons from 2 patients with keratoconus who had undergone DALK surgery using the "big-bubble" technique were examined by light microscopy.
Purpose: To describe the histopathologic characteristics of a 51-year-old Castroviejo square graft that remained functional for more than 50 years and to describe the wound-healing characteristics over this period of time.
Methods: An 80-year-old woman with a history of keratoconus underwent penetrating keratoplasty with square grafts in 1956 and 1957 in the right and left eyes, respectively. The graft from the right eye was replaced in 2007, and the corneal specimen was submitted for histopathologic analysis.
Purpose: To report the histologic and immunohistochemical features of a congenital vitreous cyst.
Methods: Interventional case report with immunohistochemical correlation. A 58-year-old woman with known vitreous cyst since childhood had an enlarging visual floater.
Objective: To assess significance of cytologically benign vitreous samples and identify cellular patterns that may correspond to specific clinical entities.
Study Design: Vitreous fluids with "negative for malignancy" cytologic diagnosis were identified from pathology department records, cytologic slides reviewed and clinical and follow-up information obtained.
Results: Fifty-four cytologically benign samples were identified (1994-2004).
Purpose: To describe the clinical and histopathologic finding of very limited ophthalmic Wegener granulomatosis (WG).
Methods: Thirteen patients with scleritis, orbitopathy, episcleritis, and panuveitis were studied. They presented without evidence of lung or kidney disease, though eight had sinus involvement.
Purpose: To describe a rare case of Mucor endophthalmitis that occurred in well-controlled diabetes after cataract surgery.
Design: Interventional case report.
Methods: Description of case and review of literature.
Purpose: To describe, test, and evaluate the pharmacokinetics of a novel posterior drug delivery system (PDS) by means of microcannulation of the suprachoroidal space in both the primate and pig animal model.
Design: Animal study.
Methods: A rhesus macaque (Macaca mulatta) (n = 1) and pig model (n = 93) were used to evaluate the PDS, a microcannula that combines a drug delivery channel with a fiber-optic illumination and optimal transition properties.
Purpose: To review our experience with triamcinolone-assisted pars plana vitrectomy for internal limiting membrane (ILM) peeling for various retinal diseases.
Methods: Twenty-one patients underwent surgery in which intraoperative triamcinolone acetonide (TA) was used. Indications for surgery included epiretinal membrane (3 patients), branch retinal vein occlusion associated with macular edema (2), traction retinal detachment (3), diabetic macular edema (4), vitreous hemorrhage with diabetic macular edema (4), macular hole (4), and cystoid macular edema (1).
Objective: To assess the effectiveness of fine needle aspiration biopsy (FNAB), with and without immunohistochemistry (IHC), in the management of solid intraocular tumors.
Study Design: Thirty-three consecutive adults undergoing FNAB of suspected intraocular tumors were studied. Clinical, cytologic and histologic diagnoses were correlated.
Purpose: To report histopathologic confirmation of the internal limiting membrane (ILM) using triamcinolone acetonide (TA).
Design: Interventional case report.
Methods: One eye of one patient who underwent macular hole repair using TA suspension to help visualize the internal limiting membrane (ILM).
Age-related delays in the uptake of norepinephrine (NE) by the rat myocardium were observed after subcutaneous injection of NE (Gey, Burkard, and Pletscher, 1965). We report here that in vitro uptake of 3H-NE by myocardial slices from healthy C57BL/6J male mice is not impaired by aging (8-28 mo.) at 0.
View Article and Find Full Text PDFThe effect of age on active transport of catecholamine precursors was studied in a healthy population of mature (12-mo.-old) and senescent (30-mo.-old) C57BL/6J male mice.
View Article and Find Full Text PDF