Automated radiosynthesis and purification of [F]flumazenil with solid phase extraction.

This paper describes the novel approach for preparation of [F]flumazenil ([F]FMZ), well known radioligand for assessment of GABA receptors by PET. The optimized reaction conditions allowed us to implement commercially available SPE cartridges for [F]FMZ purification avoiding HPLC. All procedures were performed with TRACERlab FX N Pro synthesizer in 53 min.