Distributed Coding of Evidence Accumulation across the Mouse Brain Using Microcircuits with a Diversity of Timescales.

The gradual accumulation of noisy evidence for or against options is the main step in the perceptual decision-making process. Using brain-wide electrophysiological recording in mice (Steinmetz et al., 2019), we examined neural correlates of evidence accumulation across brain areas.

Online spike sorting via deep contractive autoencoder.

Spike sorting - the process of separating spikes from different neurons - is often the first and most critical step in the neural data analysis pipeline. Spike-sorting techniques isolate a single neuron's activity from background electrical noise based on the shapes of the waveforms obtained from extracellular recordings. Despite several advancements in this area, an important remaining challenge in neuroscience is online spike sorting, which has the potential to significantly advance basic neuroscience research and the clinical setting by providing the means to produce real-time perturbations of neurons via closed-loop control.

Brain-behavior relationships in the perceptual decision-making process through cognitive processing stages.

Perceptual decision making - the process of detecting and categorizing information - has been studied extensively over the last two decades. In this study, we aim to bridge the gap between neural and behavioral representations of the perceptual decision-making process. The neural characterization of decision-making was investigated by evaluating the duration and neural signature of the information processing stages.

Correlations between EEG and clinical outcome in chronic neuropathic pain: surgical effects and treatment resistance.

Chronic neuropathic pain may require a neurosurgical treatment, but for reasons that have not been fully explored yet, a significant number of patients do not benefit from the intervention. We compared the resting EEG of 15 healthy controls to the EEG of 23 chronic neuropathic pain patients before and 12 months after treatment by the central lateral thalamotomy (CLT). A patient subgroup had a high (n = 14, pain relief (PR)  ≥ 50%) and another subgroup a low (n = 9, PR < 50%) postoperative PR.

Temporo-insular enhancement of EEG low and high frequencies in patients with chronic tinnitus. QEEG study of chronic tinnitus patients.

Background: The physiopathological mechanism underlying the tinnitus phenomenon is still the subject of an ongoing debate. Since oscillatory EEG activity is increasingly recognized as a fundamental hallmark of cortical integrative functions, this study investigates deviations from the norm of different resting EEG parameters in patients suffering from chronic tinnitus.

Results: Spectral parameters of resting EEG of male tinnitus patients (n = 8, mean age 54 years) were compared to those of age-matched healthy males (n = 15, mean age 58.

Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients.

Oscillatory and coherent EEG activity is increasingly recognized as a fundamental hallmark of cortical integrative functions. We aimed to study deviations from the norm of different resting EEG parameters in Parkinson's disease (PD) patients. We compared spectral parameters of the resting EEG of PD patients (n=24, median age 67 years) to those of healthy controls (n=34, median age 62 years).

EEG alpha distinguishes between cuneal and precuneal activation in working memory.

In the literature on EEG during working memory (WM), the role of alpha power (8-13 Hz) during WM retention has remained unclear. We recorded EEG while 18 subjects retained sets of consonants in memory for 3 s; setsize (ss4, ss6, ss8) determines memory workload. Theta power (4-8 Hz) increased with workload in all subjects in middle frontal electrodes.