A randomized controlled trial evaluating the impact of selective axillary nerve block after arthroscopic subacromial decompression.

Background: The sensory innervation of the shoulder is complex and there are variations in the branching patterns of the sensory fibres. Articular branches from the axillary nerve to the subacromial bursa are described in more than 50% of investigated shoulders but the isolated contribution of sensory input from the axillary nerve has never been investigated clinically. We hypothesized that a selective block of the axillary nerve would reduce morphine consumption and pain after arthroscopic subacromial decompression.

Pharmacokinetics of Repeated Melatonin Drug Administrations Prior to and After Surgery.

Background: Recent clinical studies have documented the analgesic, anti-inflammatory, antioxidative and anxiolytic effects of exogenous melatonin. The pharmacokinetic properties of melatonin have primarily been investigated in experimental studies.

Objective: The aim of this study was to estimate the pharmacokinetics of melatonin in patients undergoing surgery and general anesthesia.