Prediction of 30-day, 90-day, and 1-year mortality after colorectal cancer surgery using a data-driven approach.

Purpose: To develop prediction models for short-term mortality risk assessment following colorectal cancer surgery.

Methods: Data was harmonized from four Danish observational health databases into the Observational Medical Outcomes Partnership Common Data Model. With a data-driven approach using the Least Absolute Shrinkage and Selection Operator logistic regression on preoperative data, we developed 30-day, 90-day, and 1-year mortality prediction models.

Combined endoscopic and laparoscopic surgery (CELS) for early colon cancer in high-risk patients.

Background: Local excision of early colon cancers could be an option in selected patients with high risk of complications and no sign of lymph node metastasis (LNM). The primary aim was to assess feasibility in high-risk patients with early colon cancer treated with Combined Endoscopic and Laparoscopic Surgery (CELS).

Methods: A non-randomized prospective feasibility study including 25 patients with Performance Status score ≥ 1 and/or American Society of Anesthesiologists score ≥ 3, and clinical Union of International Cancer Control stage-1 colon cancer suitable for CELS resection.

The risk of lymph node metastasis in patients with T2 colon cancer.

Aim: It is often safe to treat pT1 tumours with local resection due to the low risk of lymph node metastasis. The risk of lymph node metastasis in pT2 colon cancer is less well investigated. The recommendation for patients diagnosed with T2 colon cancer is a segmental resection including regional lymph nodes.

Risk factors for lymph node metastasis in patients with pT2 colon cancer in Denmark from 2016 to 2019-A nationwide cohort study.

Aim: The majority of patients with pT2 colon cancer have no lymph node metastasis (LNM). Knowledge of risk factors for LNM in pT2 colon cancer could identify patients at low risk and thereby potential candidates for local tumour excision. The aim of this work was to identify risk factors for LNM in pT2 colon cancer and describe a subgroup of low-risk patients.

Preoperative prediction of lymph node status in patients with colorectal cancer. Developing a predictive model using machine learning.

Purpose: Develop a prediction model to determine the probability of no lymph node metastasis (pN0) in patients with colorectal cancer.

Methods: We used data from four Danish health databases on patients with colorectal cancer diagnosed between 2001 and 2019. The registries were harmonized into one common data model (CDM).

[Colon cancer surgery in the high-risk patient].

The incidence of colon cancer increases with age. With national screening in Denmark, the incidence of early stage cancer is high. With the increasing possibilities of personalised treatment for colon cancer, it is important to choose the right treatment for the right patient.

Anastomotic Leakage After Stoma Reversal Combined with Incisional Hernia Repair.

Background: Stoma reversal in patients with an incisional hernia represents a clinical dilemma, as it remains unknown whether hernia repair should be concomitantly employed. We aimed at examining postoperative complications and mortality in patients undergoing stoma reversal with or without concomitant hernia repair.

Methods: This study included all patients subjected to stoma reversal between 2010 and 2016 at our institution.

Local involvement of the lower urinary tract in primary colorectal cancer - outcome after en-bloc resection.

Unlabelled: Invasion of urinary organs due to advanced colorectal cancer can comprise a surgical challenge in achieving negative resection margins. The aim of the study was to asses the outcome of patients with colorectal cancer invading the lower urinary organs.

Material And Methods: This is a cohort study that retrospectively evaluated the surgical and pathological findings after the resection of colorectal cancer with adjacent urological organs due to advanced colorectal cancer.